This project is devoted to test the hypothesis that brain tumors in high risk groups could be triggered by the presence of a germ line mutation in tumor suppressor genes, specifically in p53. The study will consist of screening several groups of pediatric and adult brain tumor patients including those with first degree relatives suffering from other malignancies, those with multiple primary neoplasms and infants under two years of age. Once the incidence of p53 germ line mutations in these high risk populations is determined, further studies will analyze the molecular and cellular evidence supporting or challenging the hypothesis that these mutations play an important role in the development of brain tumors in these selected populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Exploratory Grants (P20)
Project #
5P20NS031088-02
Application #
3783259
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012
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