Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the proposed research is to study the potential anatomic and metabolic changes in the developing human nervous system associated with prenatal methamphetamine (MA) exposure, and the relationship of these changes to measurable alterations in child behavior and development in the preschool period. Preliminary studies suggest that prenatal MA exposure is associated with alterations in the volume and biochemical composition of specific CNS regions, and with disordered attention and verbal memory.
The specific aims of the proposal are: (1) to identify the effects of prenatal MA exposure on CNS structure and metabolism in three-year-old children, and (2) to examine the relationship between prenatal MA exposure, CNS structure and metabolism, and two cognitive domains, attention and arousal/self-regulation, assessed at 2 and 3 years of age.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR011091-12
Application #
7380994
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-07-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
12
Fiscal Year
2006
Total Cost
$53,129
Indirect Cost

  Institution

Name
University of Hawaii
Department
Type
Organized Research Units
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822

  Publications

Petrov, Andrii Y; Herbst, Michael; Andrew Stenger, V (2017) Improving temporal resolution in fMRI using a 3D spiral acquisition and low rank plus sparse (L+S) reconstruction. Neuroimage 157:660-674
Foli, Karen J; Hebdon, Megan; Lim, Eunjung et al. (2017) Transitions of Adoptive Parents: A Longitudinal Mixed Methods Analysis. Arch Psychiatr Nurs 31:483-492
Chuang, Eleanore; Lim, Eunjung; Milne, Cris et al. (2016) Human Papillomavirus at Multiple Sites Associated with Anal Squamous Intraepithelial Lesions in HIV-Seropositive Individuals. Ann Clin Cytol Pathol 2:
Deng, Weiran; Zahneisen, Benjamin; Stenger, V Andrew (2016) Rotated stack-of-spirals partial acquisition for rapid volumetric parallel MRI. Magn Reson Med 76:127-35
Garcia, Alan F; Yamaga, Karen M; Shafer, Leigh Anne et al. (2016) Cardiac Myosin Epitopes Recognized by Autoantibody in Acute and Convalescent Rheumatic Fever. Pediatr Infect Dis J 35:1021-6
Steinemann, Susan; Kurosawa, Gene; Wei, Alexander et al. (2016) Role confusion and self-assessment in interprofessional trauma teams. Am J Surg 211:482-8
Yamasato, Kelly; Kaneshiro, Bliss; Salcedo, Jennifer (2015) Neuraxial blockade for external cephalic version: Cost analysis. J Obstet Gynaecol Res 41:1023-31
Pokhrel, Pallav; Fagan, Pebbles; Kehl, Lisa et al. (2015) Receptivity to e-cigarette marketing, harm perceptions, and e-cigarette use. Am J Health Behav 39:121-31
Smith, Lynne M; Diaz, Sabrina; LaGasse, Linda L et al. (2015) Developmental and behavioral consequences of prenatal methamphetamine exposure: A review of the Infant Development, Environment, and Lifestyle (IDEAL) study. Neurotoxicol Teratol 51:35-44
Shikuma, Cecilia M; Bennett, Kara; Ananworanich, Jintanat et al. (2015) Distal leg epidermal nerve fiber density as a surrogate marker of HIV-associated sensory neuropathy risk: risk factors and change following initial antiretroviral therapy. J Neurovirol 21:525-34

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