To compare the steady state area under the concentration-time-curve between 0 and 12 hours (AUCo-12) of ZDV-MP, ZDV-TP, and dTTP in PBMCs from HIV-HCV co-infected patients before and after REBETRON(r) OR PEG-lNTRON(tm) plus Ribavirin therapy. To compare the systemic exposure (AUCo-12) of nelfinavir before and after Rebetron OR PEGINTRON (tm) plus Ribavirin therapy in HIV-HCV co-infected patients. ? ? To describe the effect of REBETRON(r) OR PEG-lNTRON(tm) plus Ribavirin in HCV-RNA viral titers, ? alanine aminotransferase (ALT) levels, CD4+, and HIV-RNA viral titers in HIV-HCV co-infected ? patients during the 48 weeks of treatment. Also, to describe the effect of REBETRON(r) OR PEGINTRON ? (tm) plus Ribavirin in liver histology at week 72. ? ?
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