Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Warfarin is a widely used drug for a number of clinical conditions requiring anticoagulant such as atrial fibrillation. However warfarin has substantial interindividual variability in dose requirements and a narrow margin between efficacy and serious toxicity. The goal of this study is to determine prospectively whether the presence of DNA Variants affect the action of anticoagulants (specifically Wafarin). This will shed light on the value of pre-prescription genotyping in improving control. This is a sub-study of the Pharmacogenics of Arrhythmia Therapy Ion Channel Variants and QT-Prolonging Antiarrhythmics-Anticoagulant Study performed in conjunction with Vanderbilt University. The sub-study involves the use of Anticoagulants (warfarin) only and not the QT prolong nation agents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR011792-09
Application #
7381060
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-08-01
Project End
2007-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
9
Fiscal Year
2006
Total Cost
$96,920
Indirect Cost

  Institution

Name
Meharry Medical College
Department
Type
Schools of Medicine
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208

  Publications

Wilkerson, Irene; Laban, Joshua; Mitchell, Johnathan M et al. (2015) Retinal pericytes and cytomegalovirus infectivity: implications for HCMV-induced retinopathy and congenital ocular disease. J Neuroinflammation 12:2
Sanderson, Maureen; O'Hara, Heather; Foderingham, Nia et al. (2015) Type 2 diabetes and mammographic breast density among underserved women. Cancer Causes Control 26:303-309
Marrs, Christy N; Knobel, Susan M; Zhu, Wen Qin et al. (2012) Evidence for Gardnerella vaginalis uptake and internalization by squamous vaginal epithelial cells: implications for the pathogenesis of bacterial vaginosis. Microbes Infect 14:500-8
Alcendor, Donald J; Charest, Ashley M; Zhu, Wen Qin et al. (2012) Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus. J Neuroinflammation 9:95
Miller, Stephania T; Marolen, Khensani (2012) Physical activity-related experiences, counseling expectations, personal responsibility, and altruism among urban African American women with type 2 diabetes. Diabetes Educ 38:229-35
Rice, Valerie Montgomery; Maimbolwa, Margaret C; Nkandu, Esther Munalula et al. (2012) Cultural differences in acceptability of a vaginal microbicide: a comparison between potential users from Nashville, Tennessee, USA, and Kafue and Mumbwa, Zambia. HIV AIDS (Auckl) 4:73-80
Choudhury, Shahana A; Ladson, Gwinnett; Hills, Edward R et al. (2011) Waning immunity to varicella in infants of human immunodeficiency virus-seropositive and -seronegative mothers. Pediatr Infect Dis J 30:799-801
Sledzi?ska, A; Mielech, A; Krawczyk, B et al. (2011) Fatal sepsis in a pregnant woman with pyelonephritis caused by Escherichia coli bearing Dr and P adhesins: diagnosis based on postmortem strain genotyping. BJOG 118:266-9
Sharan, Chakradhari; Halder, Sunil K; Thota, Chandrasekhar et al. (2011) Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertil Steril 95:247-53
Alcendor, Donald J; Knobel, Susan; Desai, Prashant et al. (2011) KSHV regulation of fibulin-2 in Kaposi's sarcoma: implications for tumorigenesis. Am J Pathol 179:1443-54

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