Abstract

The overall goal of this project is to identify and characterize novel molecules that may be involved in the behavioral sensitization of methamphetamine (MAP) and combined methamphetamine and alcohol-induced behavioral sensitization. The hypothesis is that combined administration of MAP and alcohol will cause greater behavioral sensitization than that produced by MAP alone, and that these changes may be correlated with changes in brain mRNA, brain proteins, or brain dopamine receptor function.
The specific aims of this study are: 1. to define the behavioral effects of acute and chronic methamphetamine and concurrent methamphetamine and alcohol administration to mice 2. to identify differentially expressed mRNAs after chronic methamphetamine and combined methamphetamine and alcohol treatment 3. to characterize the single and combined drug effects of methamphetamine and alcohol on dopamine D1 and D2 binding sites and dopamine receptor mediated cAMP activity in selective brain areas.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
3P20RR011808-05S1
Application #
6502076
Study Section
Project Start
2001-09-30
Project End
2002-09-29
Budget Start
Budget End
Support Year
5
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Tennessee State University
Department
Type
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37209

  Publications

Johnson, A L; Goode, G D; Mtshali, C et al. (2007) Protein Kinase C- alpha/betaII, delta, and zeta/lambda involvement in ethanol-induced MAPK expression in vascular smooth muscle cells. Cell Mol Biol (Noisy-le-grand) 53:38-44
Jones, C D; Bartee, J A; Leite-Browning, M L et al. (2007) Methamphetamine-induced locomotor activity and behavioral sensitization: are dopamine d3 receptors involved? Cell Mol Biol (Noisy-le-grand) 53:15-22
Shaw, J B; Cai, Q; Mtshali, C et al. (2007) Heterogeneity of histamine H3 receptor genomic expression in the cerebral cortex of spontaneously hypertensive rat. Cell Mol Biol (Noisy-le-grand) 53:45-50
Cao, Z; Wang, Y; McAdory, B S et al. (2006) Identification and characterization of syntaxin 1 antisense variants in Limulus polyphemus. Cell Mol Neurobiol 26:53-66
Washington, Benny; Williams, Shunta; Armstrong, Patrice et al. (2006) Cadmium toxicity on arterioles vascular smooth muscle cells of spontaneously hypertensive rats. Int J Environ Res Public Health 3:323-8
Reid, Easton A; Cao, Zheng; Wang, Yilun et al. (2003) Molecular cloning and identification of a putative PKC epsilon cDNA from Limulus polyphemus brain. Life Sci 72:961-76
Washington, B; Mtshali, C; Williams, S et al. (2003) Ethanol-induced mitogen activated protein kinase activity mediated through protein kinase C. Cell Mol Biol (Noisy-le-grand) 49:1351-6
Ivy, M T; Newkirk, R F; Karim, M R et al. (2001) Hemicholinium-3 mustard reveals two populations of cycling choline cotransporters in Limulus. Neuroscience 102:969-78
Washington, B; Butler, K; Doye, A A et al. (2001) Heart function challenged with beta-receptor agonism or antagonism in a heart failure model. Cardiovasc Drugs Ther 15:479-86
Washington, B; Shaw, J B; Li, J et al. (2000) In vivo histamine release from brain cortex: the effects of modulating cellular and extracellular sodium and calcium channels. Eur J Pharmacol 407:117-22

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