EXCEED THE SPACEPROVIDED.Core A of the COBRE grant, the administrative and mentoring core, will provide (1) administrative leadershipand coordination of the overall research effort, (2) offer expert external review, mentoring, and consultation forthe optimal progress of the scientific research effort and the professional development of the mentees, (3)enhance communication of research results by organizing meetings, workshops, and symposia related tocancer research, and data sharing, and provide appropriate accounting and other management support.The major responsibilities of Core A will involve the administration of five COBRE projects, replacement ofCOBRE projects, First Awards selection, and start-up enhancement package selection. This process willinvolve external peer-review. Core A will also oversee three scientific cores, (1) High Throughput Screening(Core B), (2) Medicinal Chemistry (Core C), and (3) the Transgenic Animal and Knock-out Mouse (TAKOM)laboratory (Core D).Experienced faculty, the Internal Advisory Board (IAB), and the External Advisory Board (EAB) will mentorthe COBRE faculty. Mentoring will also take place through participation and organization of workshops,symposia, and seminars, including grant-writing workshops.Core A will also manage the monthly COBRE meetings, the IAB and EAB meetings, the NIH-data sharingplan, prepare the annual progress report, manage a COBRE website, and keep the COBRE brochureupdated. Core A is also responsible for accounting management.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015563-10
Application #
7608740
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Program Officer
Sayre, Michael
Project Start
2000-09-30
Project End
2010-08-31
Budget Start
2009-03-01
Budget End
2010-08-31
Support Year
10
Fiscal Year
2009
Total Cost
$1,929,034
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Subramanian, Chitra; Grogan, Patrick T; Opipari, Valerie P et al. (2018) Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt/mTOR/NF-?B activation. Oncotarget 9:14509-14523
Ishiguro, Susumu; Kawabata, Atsushi; Zulbaran-Rojas, Alejandro et al. (2018) Co-treatment with a C1B5 peptide of protein kinase C? and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation. Biochem Biophys Res Commun 495:962-968
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Li, Benyi; Thrasher, James Brantley; Terranova, Paul (2015) Glycogen synthase kinase-3: a potential preventive target for prostate cancer management. Urol Oncol 33:456-63
Ishiguro, Susumu; Yoshimura, Kiyoshi; Tsunedomi, Ryouichi et al. (2015) Involvement of angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice. Cancer Biol Ther 16:307-16
Standard, Joseph; Jiang, Yu; Yu, Miao et al. (2014) Reduced signaling of PI3K-Akt and RAS-MAPK pathways is the key target for weight-loss-induced cancer prevention by dietary calorie restriction and/or physical activity. J Nutr Biochem 25:1317-23
Peterson, Kenneth R; Costa, Flávia C; Fedosyuk, Halyna et al. (2014) A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies. PLoS One 9:e107006
Kong, Bo; Huang, Jiansheng; Zhu, Yan et al. (2014) Fibroblast growth factor 15 deficiency impairs liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol 306:G893-902

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