This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Androgens amplify hypertension development. The mechanisms of this prohypertensive effect remain to be determined. Current evidence supports the view that the hypothalamic paraventricular nucleus is a key forebrain site involved in the hypertensive process by way of increasing sympathetic outflow to the cardiovascular system. Peak involvement of the PVN appears to be during the developmental stages of hypertension which corresponds to a time of peak sympathetic activity and a surge in androgen secretion. Accordingly, the proposed experiments are designed to test the hypothesis that impairment of androgen action in the hypothalamic paraventricular nucleus will attenuate the development of genetic hypertension. The project will make use of an RNA silencing approach to selectively impair androgen receptor function in the PVN of male SHR at the prehypertensive stage and then track blood pressure through the developmental stages (~6 weeks) of hypertension using radiotelemetry.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015567-07
Application #
7381111
Study Section
Special Emphasis Panel (ZRR1-RI-8 (02))
Project Start
2006-06-01
Project End
2007-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
7
Fiscal Year
2006
Total Cost
$16,779
Indirect Cost
Name
University of South Dakota
Department
Neurosciences
Type
Schools of Medicine
DUNS #
929930808
City
Vermillion
State
SD
Country
United States
Zip Code
57069
Burrell, Brian D (2017) Comparative biology of pain: What invertebrates can tell us about how nociception works. J Neurophysiol 117:1461-1473
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Hahn, Elizabeth; Burrell, Brian (2015) Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech. Invert Neurosci 15:177
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Ranek, Mark J; Kost Jr, Curtis K; Hu, Chengjun et al. (2014) Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner. J Mol Cell Cardiol 69:43-51
Watt, Michael J; Roberts, Christina L; Scholl, Jamie L et al. (2014) Decreased prefrontal cortex dopamine activity following adolescent social defeat in male rats: role of dopamine D2 receptors. Psychopharmacology (Berl) 231:1627-36

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