EXCEED THE SPACEPROVIDED. The initial COBRE grant established the Sensory Neuroscience Research Center (SNRC) with a multidisciplinary nucleus of independent investigators at West Virginia University. This COBRE support stimulated institutional commitments for new tenure-track salary lines and the construction of modern laboratory space for SNRC expansion and enabled SNRC investigators to obtain R01 funding. We request a second phase of COBRE support to complete the development of a self-sustaining research enterprise, and thereby increase the research capacity of our institution. We propose 4 specific aims.
Aim 1 is to achieve a critical mass of independently funded scientists. We have grown from 4 to 10 WVU investigators during the current funding period. In this application, 5 of these scientists have proposed new projects to aid transition to independent R01 funding. With proposed grant support we will further expand to 14 faculty members by recruiting established scientists, especially clinician investigators to broaden our studies of mechanisms of sensory disorders.
Aim 2 is to advance understanding of sensory systems by fostering new collaborations among faculty, thereby integrating new investigators into the Center. Recent and projected recruits extend the collective scope of our work and add new technical expertise that underlies unique opportunities for scientific interaction.
Aim 3 is to expand institutional research infrastructure through expansion of core facilities. Support is requested for SNRC core facilities for research and administrative activities, personnel to administer these cores, and partial support for institutional core facilities that are central to SNRC research efforts.
Aim 4 is to transition the SNRC to independent status. With further COBRE support, we will obtain a strong base of R01 funding that underpins applications for research core and program project grants. Our Health Sciences Center has implemented a strategic research plan to provide resources for infrastructure and faculty recruitment and increase the number of qualified graduate students to train in our laboratories and support our research programs. Five research projects encompassing four sensory systems (auditory, olfactory, somatosensory, and visual) are proposed. These projects reflect the multidisciplinary approach of SNRC, which includes the comparison across sensory modalities and multiple levels of analysis (molecular to systems), in species ranging from invertebrates through humans.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-8 (02))
Program Officer
Maruvada, Padma
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
West Virginia University
Schools of Medicine
United States
Zip Code
Rodgers, H M; Huffman, V J; Voronina, V A et al. (2018) The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification. Mech Dev 151:18-29
Khawaja, Anthony P; Cooke Bailey, Jessica N; Wareham, Nicholas J et al. (2018) Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nat Genet 50:778-782
Lewis, James W; Silberman, Magenta J; Donai, Jeremy J et al. (2018) Hearing and orally mimicking different acoustic-semantic categories of natural sound engage distinct left hemisphere cortical regions. Brain Lang 183:64-78
Brefczynski-Lewis, Julie A; Lewis, James W (2017) Auditory object perception: A neurobiological model and prospective review. Neuropsychologia 105:223-242
Pasquale, Louis R (2016) Vascular and autonomic dysregulation in primary open-angle glaucoma. Curr Opin Ophthalmol 27:94-101
Rodgers, Helen M; Belcastro, Marycharmain; Sokolov, Maxim et al. (2016) Embryonic markers of cone differentiation. Mol Vis 22:1455-1467
Li, Zheng; Allingham, R Rand; Nakano, Masakazu et al. (2015) A common variant near TGFBR3 is associated with primary open angle glaucoma. Hum Mol Genet 24:3880-92
Springelkamp, Henriët; Höhn, René; Mishra, Aniket et al. (2014) Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. Nat Commun 5:4883
Loomis, Stephanie J; Kang, Jae H; Weinreb, Robert N et al. (2014) Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss. Ophthalmology 121:508-16
Ozel, A Bilge; Moroi, Sayoko E; Reed, David M et al. (2014) Genome-wide association study and meta-analysis of intraocular pressure. Hum Genet 133:41-57

Showing the most recent 10 out of 63 publications