EXCEED THE SPACEPROVIDED.This COBRE renewal brings together 5 junior or just recently funded Principal Investigators whose researchfocuses on spinal cord injury (SCI) and repair. They will be mentored by 3 senior Investigators with strongtrack records in SCI research. Five Cores will be extensively used by all of these Projects. This COBRErepresents a true Research Center and not a collection of individual Projects, as the expertise of theseInvestigators is broad based and the success of individual Projects will depend on strong collaborations withother Projects and Cores.
The Specific Aims of this COBRE are:1. To develop new therapeutic approaches to the treatment of SCI that can be utilized clinically.2. To further strengthen the independent research programs of each Principal Investigator that will ultimatelylead to additional R01 or P01 support.3. To continue to develop and support the KSCIRC infrastructure through its Core facilities.4. To facilitate collaborative research projects between the COBRE Principal Investigators, as well as otherUniversity of Louisville faculty that will lead to significant scientific findings that are unlikely to be achieved byindividual research activities.5. To continue to be a leading SCI Research Center, recognized both nationally and internationally, anddevelop a reputation that will attract outstanding graduate students, postdoctoral! fellows, and faculty.The five Projects are: 1) Heat shock proteins in spinal cord neural survival, 2) GSK3B as a target for pro-neuronal survival in CMS neurons, 3) Remyelination as a mechanism for spinal cord repair, 4) PKCregulation of sensory regeneration across CSPG after SCI, and 5) Gender differences in chronic SCI pain.The 5 Cores are: Administrative and Research Support, Cell Culture and Molecular Biology, Surgery andVeterinary Care, Electrophysiology and Behavior, and Microscopy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015576-08
Application #
7266243
Study Section
Special Emphasis Panel (ZRR1-RI-8 (02))
Program Officer
Gorospe, Rafael
Project Start
2000-09-15
Project End
2010-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
8
Fiscal Year
2007
Total Cost
$2,036,224
Indirect Cost
Name
University of Louisville
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
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Kuypers, Nicholas J; Bankston, Andrew N; Howard, Russell M et al. (2016) Remyelinating Oligodendrocyte Precursor Cell miRNAs from the Sfmbt2 Cluster Promote Cell Cycle Arrest and Differentiation. J Neurosci 36:1698-710
Myers, Scott A; Bankston, Andrew N; Burke, Darlene A et al. (2016) Does the preclinical evidence for functional remyelination following myelinating cell engraftment into the injured spinal cord support progression to clinical trials? Exp Neurol 283:560-72
May, Zacnicte; Fouad, Karim; Shum-Siu, Alice et al. (2015) Challenges of animal models in SCI research: Effects of pre-injury task-specific training in adult rats before lesion. Behav Brain Res 291:26-35
Jagadapillai, Rekha; Mellen, Nicholas M; Sachleben Jr, Leroy R et al. (2014) Ceftriaxone preserves glutamate transporters and prevents intermittent hypoxia-induced vulnerability to brain excitotoxic injury. PLoS One 9:e100230
Nielson, Jessica L; Guandique, Cristian F; Liu, Aiwen W et al. (2014) Development of a database for translational spinal cord injury research. J Neurotrauma 31:1789-99
Ward, Patricia J; Herrity, April N; Smith, Rebecca R et al. (2014) Novel multi-system functional gains via task specific training in spinal cord injured male rats. J Neurotrauma 31:819-33
Kuypers, Nicholas J; James, Kurtis T; Enzmann, Gaby U et al. (2013) Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord. Exp Neurol 247:615-22
Schultz, R L; Kullman, E L; Waters, R P et al. (2013) Metabolic adaptations of skeletal muscle to voluntary wheel running exercise in hypertensive heart failure rats. Physiol Res 62:361-9
Burke, Darlene A; Whittemore, Scott R; Magnuson, David S K (2013) Consequences of common data analysis inaccuracies in CNS trauma injury basic research. J Neurotrauma 30:797-805

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