Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background and Objective: Influenza infections result in significant morbidity andmortality each year especially in individuals with autoimmune disorders, such as systemic lupus erythematosus (lupus). This study was designed to examine the viral susceptibility, anti-influenza response, and autoimmune disease development following viral infection of lupus-prone mice. Methods: MRL and MRL-lpr mice were inoculated with either saline or influenza virus and samples were collected at several time-points post infection. These samples were used to monitor viral titers, cytokine production, anti-influenza antibodies, autoantibodies, and kidney disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015577-10
Application #
7959380
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2009-03-01
Project End
2010-02-28
Budget Start
2009-03-01
Budget End
2010-02-28
Support Year
10
Fiscal Year
2009
Total Cost
$208,248
Indirect Cost

  Institution

Name
Oklahoma Medical Research Foundation
Department
Type
DUNS #
077333797
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104

  Publications

Hu, Zihua; Jiang, Kaiyu; Frank, Mark Barton et al. (2018) Modeling Transcriptional Rewiring in Neutrophils Through the Course of Treated Juvenile Idiopathic Arthritis. Sci Rep 8:7805
Hu, Zihua; Jiang, Kaiyu; Frank, Mark Barton et al. (2016) Complexity and Specificity of the Neutrophil Transcriptomes in Juvenile Idiopathic Arthritis. Sci Rep 6:27453
Molineros, Julio E; Maiti, Amit K; Sun, Celi et al. (2013) Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet 9:e1003222
Smith, Kenneth; Muther, Jennifer J; Duke, Angie L et al. (2013) Fully human monoclonal antibodies from antibody secreting cells after vaccination with Pneumovax®23 are serotype specific and facilitate opsonophagocytosis. Immunobiology 218:745-54
Dozmorov, Igor; Dominguez, Nicolas; Sestak, Andrea L et al. (2013) Evidence of dynamically dysregulated gene expression pathways in hyperresponsive B cells from African American lupus patients. PLoS One 8:e71397
Jiang, Kaiyu; Frank, Mark; Chen, Yanmin et al. (2013) Genomic characterization of remission in juvenile idiopathic arthritis. Arthritis Res Ther 15:R100
Kurien, Biji T; D'Sousa, Anil; Bruner, Benjamin F et al. (2013) Prolidase deficiency breaks tolerance to lupus-associated antigens. Int J Rheum Dis 16:674-80
Castillejo-López, Casimiro; Delgado-Vega, Angélica M; Wojcik, Jerome et al. (2012) Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. Ann Rheum Dis 71:136-42
Bruner, Benjamin F; Guthridge, Joel M; Lu, Rufei et al. (2012) Comparison of autoantibody specificities between traditional and bead-based assays in a large, diverse collection of patients with systemic lupus erythematosus and family members. Arthritis Rheum 64:3677-86
Kim, Kwangwoo; Brown, Elizabeth E; Choi, Chan-Bum et al. (2012) Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis 71:1809-14

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