This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.A major goal of the COBRE project is to enhance research competitiveness by increasing the access investigators have to state-of-the-art equipment through the development of core facilities. As outlined on our organizational chart, investigators have access to six critically needed Core Research Facilities (CRFs) on campus. Four of these CRFs are directly funded by the COBRE CSFN: Mass Spectroscopy and Proteomics, Molecular Histology and Fluorescence Imaging, Molecular Computation and Modeling, and BioSpectroscopy. Importantly, these CRFs are supported not only by the present COBRE award, but also by the University Research Office and State of Montana match funding, as well as by NIH and NSF grants awarded to UM. The CRFs have continued to develop and, as planned, have served not only to enhance individual projects but also to promote collaborations. Projects emerging from these cores have begun to produce publications and to be included as a critical resource in a number of funded R01 applications by CSFN investigators as well as in submitted applications. It should be noted in this regard that in almost every instance the RO1 review sheets from submitted grants (scored and unscored) continue to characterize the research environment as very supportive of the proposed projects.
| Gates, Christina; Backos, Donald S; Reigan, Philip et al. (2018) Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4. Bioorg Med Chem 26:4797-4803 |
| Bayat Mokhtari, Elham; Lawrence, J Josh; Stone, Emily F (2018) Data Driven Models of Short-Term Synaptic Plasticity. Front Comput Neurosci 12:32 |
| Gupta, Tarun; Morgan, Hannah R; Andrews, Jonathan C et al. (2017) Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila. Sci Rep 7:5420 |
| Steiger, Scott A; Li, Chun; Backos, Donald S et al. (2017) Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter. Bioorg Med Chem 25:3223-3234 |
| Stine, Jessica M; Ahl, Gabriel J H; Schlenker, Casey et al. (2017) The Interaction between the Third Type III Domain from Fibronectin and Anastellin Involves ?-Strand Exchange. Biochemistry 56:4667-4675 |
| Park, Sunyoung; Nevin, Andrew B C; Cardozo-Pelaez, Fernando et al. (2016) Pb exposure prolongs the time period for postnatal transient uptake of 5-HT by murine LSO neurons. Neurotoxicology 57:258-269 |
| Gábriel, Robert; Erdélyi, Ferenc; Szabó, Gábor et al. (2016) Ectopic transgene expression in the retina of four transgenic mouse lines. Brain Struct Funct 221:3729-41 |
| Gupta, T; Morgan, H R; Bailey, J A et al. (2016) Functional conservation of MBD proteins: MeCP2 and Drosophila MBD proteins alter sleep. Genes Brain Behav 15:757-774 |
| Steiger, Scott A; Li, Chun; Campana, Charles F et al. (2016) Lanthanide and asymmetric catalyzed syntheses of sterically hindered 4-isoxazolyl-1,4-dihydropyridines and 4-isoxazolyl-quinolones. Tetrahedron Lett 57:423-425 |
| Lacher, Sarah E; Skagen, Kasse; Veit, Joachim et al. (2015) P-Glycoprotein Transport of Neurotoxic Pesticides. J Pharmacol Exp Ther 355:99-107 |
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