? This proposal is for supplemental funding to allow acquisition of several items of research equipment to enhance the capabilities available within the Center of Biomedical Research Excellence in Structural and Functional Genomics at the University of Delaware. The items to be acquired are: ? ? ? Digilab Fourier transform infrared spectrometer; ? ? AVIV circular dichroism spectrometer; ? ? Microcal titration calorimeter; ? ? Amersham Biosciences Typhoon scanner; ? ? Beckman-Coulter ultracentrifuge with suitable rotors. ? ? Most of the requested items will be incorporated in a new shared core facility that has been established within the College of Engineering, and all will be available for use by all University life sciences research groups. ? ? The requested items of equipment will support the Core research aims of the Center in seeking to characterize protein structure - function relationships implicated in elucidating the larger genotype - phenotype relation. The research that will be directly supported includes all the experimental projects within the Center, both the original core subprojects and pilot projects, as well as the research efforts of a large group of additional faculty. Expansion of the research infrastructure by addition of the requested equipment will greatly streamline the research efforts of these investigators, and is also expected to improve the ability of the University in general, and the College of Engineering in particular, to recruit new faculty in the molecular biosciences. ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
3P20RR015588-04S1
Application #
6707705
Study Section
Special Emphasis Panel (ZRR1-RI-2 (01))
Program Officer
Maruvada, Padma
Project Start
2000-09-30
Project End
2005-06-30
Budget Start
2003-09-01
Budget End
2004-06-30
Support Year
4
Fiscal Year
2003
Total Cost
$500,000
Indirect Cost
Name
University of Delaware
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Li, Linqing; Stiadle, Jeanna M; Levendoski, Elizabeth E et al. (2018) Biocompatibility of injectable resilin-based hydrogels. J Biomed Mater Res A 106:2229-2242
Bathala, Pradeepthi; Fereshteh, Zeinab; Li, Kun et al. (2018) Oviductal extracellular vesicles (oviductosomes, OVS) are conserved in humans: murine OVS play a pivotal role in sperm capacitation and fertility. Mol Hum Reprod 24:143-157
Olli, Kristine E; Li, Kun; Galileo, Deni S et al. (2018) Plasma membrane calcium ATPase 4 (PMCA4) co-ordinates calcium and nitric oxide signaling in regulating murine sperm functional activity. J Cell Physiol 233:11-22
Wu, Kathie Z; Li, Kun; Galileo, Deni S et al. (2017) Junctional adhesion molecule A: expression in the murine epididymal tract and accessory organs and acquisition by maturing sperm. Mol Hum Reprod 23:132-140
Li, Linqing; Stiadle, Jeanna M; Lau, Hang K et al. (2016) Tissue engineering-based therapeutic strategies for vocal fold repair and regeneration. Biomaterials 108:91-110
Martin-DeLeon, Patricia Anastasia (2016) Uterosomes: Exosomal cargo during the estrus cycle and interaction with sperm. Front Biosci (Schol Ed) 8:115-22
Al-Dossary, Amal A; Bathala, Pradeepthi; Caplan, Jeffrey L et al. (2015) Oviductosome-Sperm Membrane Interaction in Cargo Delivery: DETECTION OF FUSION AND UNDERLYING MOLECULAR PLAYERS USING THREE-DIMENSIONAL SUPER-RESOLUTION STRUCTURED ILLUMINATION MICROSCOPY (SR-SIM). J Biol Chem 290:17710-23
Monillas, Elizabeth S; Caplan, Jeffrey L; Thévenin, Anastasia F et al. (2015) Oligomeric state regulated trafficking of human platelet-activating factor acetylhydrolase type-II. Biochim Biophys Acta 1854:469-75
Andrews, Rachel E; Galileo, Deni S; Martin-DeLeon, Patricia A (2015) Plasma membrane Ca2+-ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca2+/CaM-dependent serine kinase. Mol Hum Reprod 21:832-43
Hu, Yuan; Sinha, Sudipta Kumar; Patel, Sandeep (2015) Investigating Hydrophilic Pores in Model Lipid Bilayers Using Molecular Simulations: Correlating Bilayer Properties with Pore-Formation Thermodynamics. Langmuir 31:6615-31

Showing the most recent 10 out of 153 publications