This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Microscopy Core Research Facility (MCRF, a unit of Center for Biotechnology) is equipped with the state of the art imaging systems including three digital imaging microscopes, two confocal laser scanning microscope and three electron microscopes. These imaging systems have been used by most of NCV members cross the UNL campus and by several members from UNMC. The MCRF has been actively involved in many studied utilizing microscopy by NCV members and associates during the FY08-09. The MCRF Manager and staff have continued strong research collaborations with at least 30 faulty/PIs and these studies used the MCRF will lead to several publications. The MRCF was utilized by 91 faculties this year (including 17 new users and 15 NCV members). The Core has also been involved in student education/training programs, and has organized demonstrations of imaging systems for ~ 200 undergraduate and ~300 high/middle school students during the FY08-09. In addition, the MCRF has been actively participating in grant application by many individual investigators and research groups (such as NCV, Redox Center, and Cell Signaling).

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015635-10
Application #
7959387
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2009-05-01
Project End
2010-04-30
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
10
Fiscal Year
2009
Total Cost
$79,675
Indirect Cost
Name
University of Nebraska Lincoln
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
555456995
City
Lincoln
State
NE
Country
United States
Zip Code
68588
De Castro, Cristina; Klose, Thomas; Speciale, Immacolata et al. (2018) Structure of the chlorovirus PBCV-1 major capsid glycoprotein determined by combining crystallographic and carbohydrate molecular modeling approaches. Proc Natl Acad Sci U S A 115:E44-E52
Yuan, Qi; Telling, Glenn; Bartelt-Hunt, Shannon L et al. (2018) Dehydration of Prions on Environmentally Relevant Surfaces Protects Them from Inactivation by Freezing and Thawing. J Virol 92:
Liu, Yilin; Jones, Clinton (2016) Regulation of Notch-mediated transcription by a bovine herpesvirus 1 encoded protein (ORF2) that is expressed in latently infected sensory neurons. J Neurovirol 22:518-28
Langenfeld, Katie A; Shikiya, Ronald A; Kincaid, Anthony E et al. (2016) Incongruity between Prion Conversion and Incubation Period following Coinfection. J Virol 90:5715-23
Liu, Yilin; Hancock, Morgan; Workman, Aspen et al. (2016) ?-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1. J Virol 90:3148-59
De Castro, Cristina; Speciale, Immacolata; Duncan, Garry et al. (2016) N-Linked Glycans of Chloroviruses Sharing a Core Architecture without Precedent. Angew Chem Int Ed Engl 55:654-8
Destache, Christopher J; Mandal, Subhra; Yuan, Zhe et al. (2016) Topical Tenofovir Disoproxil Fumarate Nanoparticles Prevent HIV-1 Vaginal Transmission in a Humanized Mouse Model. Antimicrob Agents Chemother 60:3633-9
Lingel, Amy; Ehlers, Erica; Wang, Qianli et al. (2016) Kaposi's Sarcoma-Associated Herpesvirus Reduces Cellular Myeloid Differentiation Primary-Response Gene 88 (MyD88) Expression via Modulation of Its RNA. J Virol 90:180-8
Liu, Fang; Huang, Yunlong; Zhang, Fang et al. (2015) Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation. J Neurochem 134:315-26
Lai, Siqiang; Zhang, Min; Xu, Dongsheng et al. (2015) Direct reprogramming of induced neural progenitors: a new promising strategy for AD treatment. Transl Neurodegener 4:7

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