Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. neurodegenerative disease that is caused by a CAG expansion within the huntingtin gene. It affects about 30000 people in the USA. Despite significant advances in our understanding of HD since identification of the gene in 1993, neuroprotective therapies are not available. Aberrant iron metabolism is implicated in the pathogenesis of neurodegenerative diseases including HD and Parkinson's disease. Theories have centered on excess iron promoting oxidative stress and cell negeneration. However, a clear understanding of the cell and subcellular locations of these processes as well as why brain iron is increased in HD is lacking. Our preliminary data suggests that alterations in iron metabolism occur early in HD and that specific modulation of iron metabolism is neuroprotective.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015640-10
Application #
8167718
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2010-07-01
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
10
Fiscal Year
2010
Total Cost
$79,304
Indirect Cost

  Institution

Name
University of Wyoming
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
069690956
City
Laramie
State
WY
Country
United States
Zip Code
82071

  Publications

Lu, Zhen; Marks, Eileen; Chen, Jianfang et al. (2014) Altered selenium status in Huntington's disease: neuroprotection by selenite in the N171-82Q mouse model. Neurobiol Dis 71:34-42
Smith, A W; Asa, C S; Edwards, B S et al. (2012) Predominant suppression of follicle-stimulating hormone ?-immunoreactivity after long-term treatment of intact and castrate adult male rats with the gonadotrophin-releasing hormone agonist deslorelin. J Neuroendocrinol 24:737-47
Dong, F; Skinner, D C; Wu, T John et al. (2011) The heart: a novel gonadotrophin-releasing hormone target. J Neuroendocrinol 23:456-63
Fox, Jonathan H; Connor, Teal; Stiles, Megan et al. (2011) Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein. J Biol Chem 286:18320-30
Green, Jade; Tyrrell, Zachary; Radosz, Maciej et al. (2011) Nanostructure of Solid Precipitates Obtained by Expansion of Polystyrene-block-Polybutadiene Solutions in Near Critical Propane: Block Ratio and Micellar Solution Effects. J Phys Chem C Nanomater Interfaces 115:9465-9470
Flynn, Francis W; Jensen, Dane D; Thakar, Amit et al. (2011) Neurokinin 3 receptor forms a complex with acetylated histone H3 and H4 in hypothalamic neurons following hyperosmotic challenge. Am J Physiol Regul Integr Comp Physiol 301:R822-31
Sladek, C D; Stevens, W; Levinson, S R et al. (2011) Characterization of nuclear neurokinin 3 receptor expression in rat brain. Neuroscience 196:35-48
Taylor, W Andrew; Evans, Neil P; Hertz, Carole et al. (2011) Intra-pituitary administration revisited: development of a novel in vivo approach to investigate the ovine hypophysis. J Neurosci Methods 199:175-82
Jensen, D D; Sundstrom, K; Flynn, F W (2010) Expression of the nuclear transport protein importin ýý-1 and its association with the neurokinin 3 receptor in the rat hypothalamus following acute hyperosmotic challenge. Neuroscience 170:1020-7
Ye, Yi; Woodbury, C Jeffery (2010) Early postnatal loss of heat sensitivity among cutaneous myelinated nociceptors in Swiss-Webster mice. J Neurophysiol 103:1385-96

Showing the most recent 10 out of 84 publications