This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The CANHR Genetics project (Boyer, project PI) is focused on the identification of genetic, and gene by environment interactions involved in the development of obesity in Yup ik Eskimos. In collaboration with investigators at Columbia University, we have recently obtained preliminary results from a candidate gene study interrogating 384 SNPs in 25 candidate genes. Preliminary association results have identified ten genes that are significantly associated with one or more obesity phenotypes in our Yup ik Eskimo study population. We are currently evaluating gene-gene and pathway interactions to identify biologically plausible pathways and networks of genes that may be implicated in obesity. We have also begun our resequencing effort to gain preliminary data for Dr. Boyer s RO1 re-submission application, and have completed resequencing four candidate genes. We selected 30 unrelated individuals from seven villages for resequencing and identified 57 SNPs, 22 (42%) of these SNPs had not been previously identified. We then analyzed all resequenced SNPs using the multimarker predictor method implemented in the Tagger program (Haploview software), and an r2 threshold of 0.8 revealed that 30 tagging SNPs will capture all of the allelic diversity found in the resequenced regions of our Yup ik samples. Although encouraging results from large-scale tagSNP portability studies have recently been published, the HapMap tagSNPs only pick up only 33% of the common variation found in the Yup ik resequenced regions. Therefore, we conclude that it is very important to resequence our candidate genes in Yup ik Eskimos. Nevertheless, we propose supplementation of our Yup ik SNP set with HapMap tagSNPs to provide higher density coverage of each gene. No changes are expected in the gender/minority composition of this subproject.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
3P20RR016430-05S1
Application #
7381225
Study Section
Special Emphasis Panel (ZRR1)
Project Start
2005-07-01
Project End
2007-06-30
Budget Start
2005-07-01
Budget End
2007-06-30
Support Year
5
Fiscal Year
2006
Total Cost
$38,371
Indirect Cost
Name
University of Alaska Fairbanks
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
615245164
City
Fairbanks
State
AK
Country
United States
Zip Code
99775
Ryman, Tove K; Boyer, Bert B; Hopkins, Scarlett E et al. (2018) Association between iq'mik smokeless tobacco use and cardiometabolic risk profile among Yup'ik Alaska Native people. Ethn Health 23:488-502
Maurice, Anne-Claire; Philip, Jacques; Bersamin, Andrea (2017) Yup'ik identity and socioeconomic status are associated with child consumption of traditional food and weight in rural Yup'ik communities. Ethn Health :1-11
Koller, Kathryn R; Flanagan, Christie A; Day, Gretchen E et al. (2017) High tobacco use prevalence with significant regional and sex differences in smokeless tobacco use among Western Alaska Native people: the WATCH study. Int J Circumpolar Health 76:1398009
Philip, Jacques; Ryman, Tove K; Hopkins, Scarlett E et al. (2017) Bi-cultural dynamics for risk and protective factors for cardiometabolic health in an Alaska Native (Yup'ik) population. PLoS One 12:e0183451
Power, Julianne M; Braun, Kathryn L; Bersamin, Andrea (2017) Exploring the Potential for Technology-Based Nutrition Education Among WIC Recipients in Remote Alaska Native Communities. J Nutr Educ Behav 49:S186-S191.e1
Lardon, Cécile; Wolsko, Christopher; Trickett, Edison et al. (2016) Assessing health in an Alaska native cultural context: The Yup'ik Wellness Survey. Cultur Divers Ethnic Minor Psychol 22:126-36
Fohner, Alison E; Wang, Zhican; Yracheta, Joseph et al. (2016) Genetics, Diet, and Season Are Associated with Serum 25-Hydroxycholecalciferol Concentration in a Yup'ik Study Population from Southwestern Alaska. J Nutr 146:318-25
Philip, Jacques; Ford, Tara; Henry, David et al. (2016) Relationship of Social Network to Protective Factors in Suicide and Alcohol Use Disorder Intervention for Rural Yup'ik Alaska Native Youth. Interv Psicosoc 25:45-54
Aslibekyan, Stella; Vaughan, Laura K; Wiener, Howard W et al. (2016) Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup'ik people. Genes Nutr 11:23
Lemas, Dominick J; Klimentidis, Yann C; Aslibekyan, Stella et al. (2016) Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. Mol Nutr Food Res 60:2642-2653

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