This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This COBRE grant to establish the Center for Alaska Native Health Research is based upon a community-based participatory research paradigm that fosters basic and applied research. The overall goal is to facilitate the development of a sustainable, NIH-funded research center specifically focused on identifying the cultural-behavioral, nutritional, and genetic risk/protective factors associated with increased weight, type two diabetes, and cardiovascular disease among Alaska Natives. The Administrative core provides infrastructure to support this research among remote rural Alaska Native communities. Accomplishments of the Administrative core for year five include: A. Received approval from three new villages to gather data. All of these villages have significant relationships historically to those villages already sampled; therefore, many individuals are related to current participants. This will increase the power of our sample for genetic analyses. B. Identified five prospective investigators for the competitive renewal whose proposals have been approved by the EAC and identified the core structures to support these projects. Received support from the villages for the renewal indicating their willingness to participate in continued research. Planned the renewal with our community partners after presenting results of the first round of data gathering. C. We have secured the continued support of the University for the space and positions needed for the renewal, which will allow us to build a long-term biomedical research program. The university has made biomedical research one of its top funding priorities when new state research dollars become available. D. Infrastructure has grown to over 60 full- and part-time investigators and support staff. This capacity has allowed us to enroll 907 Yup ik participants in the study. It has stimulated submissions of one R01, one R24, two R21s, one R03, and one R34. Four R-series grants were received by CANHR investigators. E. Productivity of CANHR investigators has significantly increased since data analysis has progressed adequately. They have presented 60 abstracts at national and regional conferences, have 20 articles or books in press, had 21 articles or book chapters published, and currently have 12 articles submitted for review.
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