Dr. Muise-Helmericks proposes to delineate the molecular mechanisms by which the potent vascular endothelial growth factor (VEGF) stimulates formation of new blood vessels. Her specific hypothesis, based on preliminary studies that included gene microarrays, is that the P13 kinase/Akt pathway is a general control point that mediates different angiogenic signals (e.g. FGF, VEGF), and that Ets-1 is a central downstream effector of this pathway.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
1P20RR016434-01
Application #
6553797
Study Section
Special Emphasis Panel (ZRR1)
Project Start
2001-09-30
Project End
2006-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
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