Abstract

The long-range goal for Dr. Hsu's project is to understand how Blc and Bax family members regulate cell death in various cardiovascular pathogenic pathways in order to eventually enable development of cardioprotective agents. He will use his considerable expertise to test the central hypothesis he pioneered: that Bcl-2 and Bcl-X block the pro-apoptotic function of Bax by preventing its redistribution from the cytosol to mitochondria during apoptosis, possibly through their respective mitochondrial receptors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016434-02
Application #
6651820
Study Section
Special Emphasis Panel (ZRR1)
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425

  Publications

Soiberman, Uri; Foster, James W; Jun, Albert S et al. (2017) Pathophysiology of Keratoconus: What Do We Know Today. Open Ophthalmol J 11:252-261
Karousou, Evgenia; Misra, Suniti; Ghatak, Shibnath et al. (2017) Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol 59:3-22
Moreno-Rodriguez, Ricardo A; Krug, Edward L; Reyes, Leticia et al. (2017) Linear array of multi-substrate tracts for simultaneous assessment of cell adhesion, migration, and differentiation. Biotechniques 63:267-274
Liu, Gang; Cooley, Marion A; Jarnicki, Andrew G et al. (2016) Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases. JCI Insight 1:
Menon, Vinal; Junor, Lorain; Balhaj, Marwa et al. (2016) A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System. J Vis Exp :
Dupuis, Loren E; Doucette, Lorna; Rice, A Kittrell et al. (2016) Development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican. Dev Dyn 245:1029-42
Olsen, T R; Mattix, B; Casco, M et al. (2015) Manipulation of cellular spheroid composition and the effects on vascular tissue fusion. Acta Biomater 13:188-98
Stevens, Shawn M; Brown, LaShardai N; Ezell, Paula C et al. (2015) The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration. J Vis Exp :
Menon, Vinal; Eberth, John F; Goodwin, Richard L et al. (2015) Altered Hemodynamics in the Embryonic Heart Affects Outflow Valve Development. J Cardiovasc Dev Dis 2:108-124
Dupuis, Loren E; Berger, Matthew G; Feldman, Samuel et al. (2015) Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly. J Mol Cell Cardiol 84:70-80

Showing the most recent 10 out of 154 publications