This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This proposal utilizes a genetically modified mouse model to explore the biological mechanisms underlying non-inflammatory joint degeneration (osteoarthritis). Although late-stage inflammatory events have been more thoroughly investigated, the initial causes of joint degeneration in osteoarthritis are unknown. Some of the causes of osteoarthritis may lie within the complex regulatory networks that orchestrate the events of development and growth of the skeleton early in life. Utilizing newly acquired information about collagen type XI and a newly developed genetically modified mouse line, we will characterize the Col11a1DVR mouse, which may reveal a new level of understanding of skeletal development and disease progression in osteoarthritis. Improved diagnosis and treatment of osteoarthritis will likely result from a more thorough understanding of factors that lead to a predisposition for the development of osteoarthritis early in life, such as those that regulate fibrillogenesis or coordinate the replacement of cartilage by bone. Evidence suggests that Col11a1 is essential in these processes. These studies may give us insight into targets for future preventive and therapeutic strategies.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016454-08
Application #
7720026
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Project Start
2008-05-01
Project End
2009-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
8
Fiscal Year
2008
Total Cost
$66,607
Indirect Cost
Name
University of Idaho
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
075746271
City
Moscow
State
ID
Country
United States
Zip Code
83844
Tawara, Ken; Bolin, Celeste; Koncinsky, Jordan et al. (2018) OSM potentiates preintravasation events, increases CTC counts, and promotes breast cancer metastasis to the lung. Breast Cancer Res 20:53
Boursier, Michelle E; Moore, Joseph D; Heitman, Katherine M et al. (2018) Structure-Function Analyses of the N-Butanoyl l-Homoserine Lactone Quorum-Sensing Signal Define Features Critical to Activity in RhlR. ACS Chem Biol 13:2655-2662
Culbertson, Vaughn L; Rahman, Shaikh E; Bosen, Grayson C et al. (2018) Implications of Off-Target Serotoninergic Drug Activity: An Analysis of Serotonin Syndrome Reports Using a Systematic Bioinformatics Approach. Pharmacotherapy 38:888-898
Gunderson, Mark P; Nguyen, Brandon T; Cervantes Reyes, Juan C et al. (2018) Response of phase I and II detoxification enzymes, glutathione, metallothionein and acetylcholine esterase to mercury and dimethoate in signal crayfish (Pacifastacus leniusculus). Chemosphere 208:749-756
Ruffley, Megan; Smith, Megan L; EspĂ­ndola, AnahĂ­ et al. (2018) Combining allele frequency and tree-based approaches improves phylogeographic inference from natural history collections. Mol Ecol 27:1012-1024
Nhu Lam, Mila; Dudekula, Dastagiri; Durham, Bri et al. (2018) Insights into ?-ketoacyl-chain recognition for ?-ketoacyl-ACP utilizing AHL synthases. Chem Commun (Camb) 54:8838-8841
McGinn, Timothy E; Mitchell, Diana M; Meighan, Peter C et al. (2018) Restoration of Dendritic Complexity, Functional Connectivity, and Diversity of Regenerated Retinal Bipolar Neurons in Adult Zebrafish. J Neurosci 38:120-136
LaFoya, Bryce; Munroe, Jordan A; Pu, Xinzhu et al. (2018) Src kinase phosphorylates Notch1 to inhibit MAML binding. Sci Rep 8:15515
Sun, Chi; Galicia, Carlos; Stenkamp, Deborah L (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics 19:127
Bowman, Kole; Rose, Jack (2017) Estradiol stimulates glycogen synthesis whereas progesterone promotes glycogen catabolism in the uterus of the American mink (Neovison vison). Anim Sci J 88:45-54

Showing the most recent 10 out of 476 publications