This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to develop algorithms and tools to advance large and multi-dimensional data processing methods geared towards biomedical data sets. They will be designed with the end user in mind, encompass powerful clustering techniques combined with visualizations, and will be easy to use and apply to any multivariate data set by an average user.
Specific Aim 1 To fully implement the proposed algorithms for occlusion resolution (currently a working prototype). To promote portability, the algorithm will be implemented in Java programming language. Streamlining the development process, we will use either Borland JBuilder or Eclipse integrated development environment (IDE). Fully implementing the algorithm also means developing a complete design and documentation using Uniform Mark-up Language (UML).
Specific Aim 2 Extend the model of neural-network enhanced visualizations from scatter plots to other visualizations and to provide support for distribution of data, providing data-driven mapping space for densely populated areas.
Specific Aim 3 Extend the algorithms to three-dimensional space to allow for visual representation of high-dimensional data sets that are three dimensional in their nature (i.e., brain data sets, multiple replications of microarray experiments, etc.).
Specific Aim 4 Introduce a model (based on Specific Aims 2 and 3) that supports the interpolation of data in a non-Euclidean representation (a SOM) and that same data in a Euclidean one (i.e., a scatter plot).
Specific Aim 5 Develop a software package, coupled with visualization techniques and user interface tools that utilize proposed algorithms, tools, and techniques. The package will be based on robust statistical and computational techniques and governed by sound software engineering approaches. All software developed as part of this project will be made available to scientific community under GNU Public License.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-4 (02))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State University A&M Col Baton Rouge
Schools of Arts and Sciences
Baton Rouge
United States
Zip Code
Hosain, Salman B; Khiste, Sachin K; Uddin, Mohammad B et al. (2016) Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells. Oncotarget 7:60575-60592
Pogue, A I; Dua, P; Hill, J M et al. (2015) Progressive inflammatory pathology in the retina of aluminum-fed 5xFAD transgenic mice. J Inorg Biochem 152:206-9
Zhang, Cheng; Rissman, Robert A; Feng, June (2015) Characterization of ATP alternations in an Alzheimer's disease transgenic mouse model. J Alzheimers Dis 44:375-8
Gu, Ying; Barzegar, Mansoureh; Chen, Xin et al. (2015) Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5. Oncotarget 6:42322-33
Pasluosta, Cristian F; Chiu, Alan W L (2015) Modulation of grasping force in prosthetic hands using neural network-based predictive control. Methods Mol Biol 1260:179-94
Ibrahim, Sulaimon; Chowriappa, Pradeep; Dua, Sumeet et al. (2015) Classification of diabetes maculopathy images using data-adaptive neuro-fuzzy inference classifier. Med Biol Eng Comput 53:1345-60
Babu, Sainath; Uppu, Sannihith N; Martin, Brittany et al. (2015) Unusually high levels of bisphenol A (BPA) in thermal paper cash register receipts (CRs): development and application of a robust LC-UV method to quantify BPA in CRs. Toxicol Mech Methods 25:410-6
El-Saadi, Madison Wynne; Williams-Hart, Tara; Salvatore, Brian A et al. (2015) Use of in-silico assays to characterize the ADMET profile and identify potential therapeutic targets of fusarochromanone, a novel anti-cancer agent. In Silico Pharmacol 3:6
Gu, Ying; Chen, Xin; Shang, Chaowei et al. (2014) Fusarochromanone induces G1 cell cycle arrest and apoptosis in COS7 and HEK293 cells. PLoS One 9:e112641
Patwardhan, Gauri A; Hosain, Salman B; Liu, David X et al. (2014) Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells. Biochim Biophys Acta 1841:1571-80

Showing the most recent 10 out of 179 publications