Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Recent experiments demonstrate close interaction between cartilage and bone compartment in vitro and in vivo, where bone cells from OA patients can cause matrix breakdown of articular cartilage and interruption of contact with subchondral bone results in cartilage degeneration. However, the communication pathway that allows cartilage and bone to interact is not clear. Dr. Wang has recently developed a method based on Fluorescence Recovery After Photobleaching (FRAP) which allows direct measurement of solute movement in the bone in situ and in real time. Drs. Wang et al. propose to use this approach in combination with mathematical modeling to characterize the solute diffusivity of representative molecules through subchondral bone plate in normal and OA joints. This project will build upon the biological foundation of project #1. Dr. Duncan will serve as mentor.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016458-07
Application #
7720204
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2008-06-01
Project End
2009-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
7
Fiscal Year
2008
Total Cost
$226,793
Indirect Cost

  Institution

Name
University of Delaware
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716

  Publications

Wellsandt, Elizabeth; Khandha, Ashutosh; Manal, Kurt et al. (2017) Predictors of knee joint loading after anterior cruciate ligament reconstruction. J Orthop Res 35:651-656
Pozzi, Federico; Marmon, Adam R; Snyder-Mackler, Lynn et al. (2016) Lower leg compensatory strategies during performance of a step up and over task in patient six-months after total knee arthroplasty. Gait Posture 49:41-46
Moore, A C; DeLucca, J F; Elliott, D M et al. (2016) Quantifying Cartilage Contact Modulus, Tension Modulus, and Permeability With Hertzian Biphasic Creep. J Tribol 138:0414051-414057
Rehmann, Matthew S; Luna, Jesus I; Maverakis, Emanual et al. (2016) Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiation. J Biomed Mater Res A 104:1162-74
Abujaber, Sumayeh; Gillispie, Gregory; Marmon, Adam et al. (2015) Validity of the Nintendo Wii Balance Board to assess weight bearing asymmetry during sit-to-stand and return-to-sit task. Gait Posture 41:676-82
Zimmerman, B K; Bonnevie, E D; Park, M et al. (2015) Role of interstitial fluid pressurization in TMJ lubrication. J Dent Res 94:85-92
Moore, A C; Zimmerman, B K; Chen, X et al. (2015) Experimental characterization of biphasic materials using rate-controlled Hertzian indentation. Tribol Int 89:2-8
Moore, A C; Burris, D L (2015) Tribological and material properties for cartilage of and throughout the bovine stifle: support for the altered joint kinematics hypothesis of osteoarthritis. Osteoarthritis Cartilage 23:161-9
Pozzi, Federico; Snyder-Mackler, Lynn; Zeni Jr, Joseph (2015) Relationship between biomechanical asymmetries during a step up and over task and stair climbing after total knee arthroplasty. Clin Biomech (Bristol, Avon) 30:78-85
Xu, Xian; Farach-Carson, Mary C; Jia, Xinqiao (2014) Three-dimensional in vitro tumor models for cancer research and drug evaluation. Biotechnol Adv 32:1256-1268

Showing the most recent 10 out of 133 publications