This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. USC proposes to support mentoring and training for faculty/graduate student teams. This approach will provide extensive mentoring and career development activities for the target faculty, as well as research training and professional development to selected graduate students in the laboratories of target faculty. In addition, SC INBRE resources at USC will be dedicated to the support of core facilities that are vital to the USC Biomedical Engineering program, as well as to SC INBRE. Three Biomedical Engineering target faculty/ PhD student teams have been identified, two of them in the CEC and one at the SOM: Drs. Blanchette, Chem Eng;Cui, SOM;and Wang, Mech Eng., will be initial target faculty. SC INBRE will provide funding for a PhD student stipend, tuition and research supplies for each team. The Mentoring teams for the target faculty will be minimally comprised of 1 senior faculty from Engineering, 1 senior faculty from SOM and 1 senior faculty from another CRU. This approach will promote collaborations and networking among USC components as well as other CRUs. The Mentoring team will meet with target faculty each quarter face-to-face or by video conference to discuss progress and provide direction. In addition, target faculty will attend grant writing workshops offered by the Sponsored Programs office. Target faculty progress will be evaluated annually by the USC INBRE Advisory Committee. The current target faculty/ graduate student teams will be funded for two years, renewable on a competitive basis. When a target faculty member obtains independent NIH funding, they will """"""""graduate"""""""" from INBRE funding and research proposals will be solicited from new target faculty/graduate student teams. The submitted proposals will be reviewed by members of the USC Institutional Advisory Committee.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016461-11
Application #
8360737
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
11
Fiscal Year
2011
Total Cost
$180,778
Indirect Cost
Name
University of South Carolina at Columbia
Department
Pathology
Type
Schools of Medicine
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208
Liang, Jiaxin; Chen, Mengqian; Hughes, Daniel et al. (2018) CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res 78:6594-6606
Emetu, Sophia; Troiano, Morgan; Goldmintz, Jacob et al. (2018) Metabolic Labeling and Profiling of Transfer RNAs Using Macroarrays. J Vis Exp :
Oprisan, Sorinel A; Buhusi, Mona; Buhusi, Catalin V (2018) A Population-Based Model of the Temporal Memory in the Hippocampus. Front Neurosci 12:521
Germany, Edward M; Zahayko, Nataliya; Huebsch, Mason L et al. (2018) The AAA ATPase Afg1 preserves mitochondrial fidelity and cellular health by maintaining mitochondrial matrix proteostasis. J Cell Sci 131:
Turner, J Phillip; Chastain, Shelby E; Park, Dongwon et al. (2017) Modulating amyloid-? aggregation: The effects of peptoid side chain placement and chirality. Bioorg Med Chem 25:20-26
Karousou, Evgenia; Misra, Suniti; Ghatak, Shibnath et al. (2017) Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol 59:3-22
Taylor, Nicholas G; Swenson, Samantha; Harris, Nicholas J et al. (2017) The Assembly Factor Pet117 Couples Heme a Synthase Activity to Cytochrome Oxidase Assembly. J Biol Chem 292:1815-1825
Lamba, Vandana; Sanchez, Enis; Fanning, Lauren Rose et al. (2017) Kemp Eliminase Activity of Ketosteroid Isomerase. Biochemistry 56:582-591
Krout, Danielle; Pramod, Akula Bala; Dahal, Rejwi Acharya et al. (2017) Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs. Biochem Pharmacol 142:204-215
Waddell, Grace L; Gilmer, Caroline R; Taylor, Nicholas G et al. (2017) The eukaryotic enzyme Bds1 is an alkyl but not an aryl sulfohydrolase. Biochem Biophys Res Commun 491:382-387

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