This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Wnt genes encode a large family of secreted molecules that play important roles in controlling tissue patterning cell fate and cell proliferation. The broad roles for Wnt genes in controlling tissue patterning, and the specific expression domains of Wnt signaling molecules in the developing gut tube suggest important roles for Wnt genes in patterning the digestive tract during development. The goal of this project is to characterize the roles of the Wnt pathways in patterning the developing gut, and understand the genetic basis for morphological change in the developing gut tube, using the little skate Raja erinacea as a model system.
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