Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
The aims of this pilot project are to establish a model system for monitoring neurite outgrowth in crustaceans and to study the influence of melatonin at the cellular and molecular levels on this process. Melatonin affects neurite growth and function in regions of the vertebrate brain, though the mechanisms are not yet known. Crustaceans provide robust and analogous systems for a variety of biomedical studies. In the first year of the project, we identified cell types that could be cultured to provide an assay for neurite growth. These cells came from the x-organ, a neurosecretory structure in the crustacean eyestalk.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016463-06
Application #
7381441
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Project Start
2006-05-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
6
Fiscal Year
2006
Total Cost
$29,844
Indirect Cost

  Institution

Name
Mount Desert Island Biological Lab
Department
Type
DUNS #
077470003
City
Salisbury Cove
State
ME
Country
United States
Zip Code
04672

  Publications

Nickerson, Chelsea A; Brown, Alexandra L; Yu, Waylin et al. (2017) Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats. Neuroscience 361:116-128
Palopoli, Michael F; Tra, Van; Matoin, Kassey et al. (2017) Evolution of host range in the follicle mite Demodex kutzeri. Parasitology 144:594-600
Mangiamele, Lisa A; Gomez, Julia R; Curtis, Nancy J et al. (2017) GPER/GPR30, a membrane estrogen receptor, is expressed in the brain and retina of a social fish (Carassius auratus) and colocalizes with isotocin. J Comp Neurol 525:252-270
Wirth, Peter; Yu, Waylin; Kimball, Amanda L et al. (2017) New method to induce mild traumatic brain injury in rodents produces differential outcomes in female and male Sprague Dawley rats. J Neurosci Methods 290:133-144
Christie, Andrew E; Roncalli, Vittoria; Cieslak, Matthew C et al. (2017) Prediction of a neuropeptidome for the eyestalk ganglia of the lobster Homarus americanus using a tissue-specific de novo assembled transcriptome. Gen Comp Endocrinol 243:96-119
Ariyachet, Chaiyaboot; Beißel, Christian; Li, Xiang et al. (2017) Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1. Mol Microbiol 104:499-519
Hahn, Mark E; Karchner, Sibel I; Merson, Rebeka R (2017) Diversity as Opportunity: Insights from 600 Million Years of AHR Evolution. Curr Opin Toxicol 2:58-71
Dickinson, Patsy S; Qu, Xuan; Stanhope, Meredith E (2016) Neuropeptide modulation of pattern-generating systems in crustaceans: comparative studies and approaches. Curr Opin Neurobiol 41:149-157
Dickinson, Patsy S; Calkins, Andrew; Stevens, Jake S (2015) Related neuropeptides use different balances of unitary mechanisms to modulate the cardiac neuromuscular system in the American lobster, Homarus americanus. J Neurophysiol 113:856-70
Palopoli, Michael F; Peden, Colin; Woo, Caitlin et al. (2015) Natural and experimental evolution of sexual conflict within Caenorhabditis nematodes. BMC Evol Biol 15:93

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