Building upon the network foundation established by BRIN, INBRE proposes to expand and to develop Hawaii's competitive biomedical research capacity. The expansion will center on three thematic projects exploring the cellular basis of immunological and neurological diseases from the perspective of immunology, cell biology, and developmental biology. Each project will be led by a well-established senior investigator who will mentor junior investigators at both the lead and the affiliated baccalaureate institutions. This will extend into the state's community colleges where participating faculty will collaborate with established researchers at the lead institution. Each investigator - senior, junior, and Outreach - will recruit and mentor undergraduate and graduate students as well. The development will concentrate on not only individual research careers but also the network's overall approach to competitive research. This involves the establishment of rigorous standards and performance expectations coupled with attentive mentoring to assist network investigators and students in meeting these challenging criteria. Organizationally, INBRE will ? consist of four major cores: Administrative, Research, Bioinformatics, and Outreach. The Administrative ? Core will provide overall administrative support, including maintenance of the network's web site, evaluation efforts, and training and mentoring workshops and seminars. The Research Core will be comprised of the three thematic research projects with a Core leader to ensure project coordination. The Outreach Core extends the research thrust into the community colleges by promoting research and student participation through collaborations with the lead and the baccalaureate institutions. The Bioinformatics Core will also provide unique opportunities by emphasizing academic work force development. To facilitate this, the Core will be housed within the University of Hawaii at Manoa's Department of Information and Computer Sciences. ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR016467-04
Application #
6813104
Study Section
Special Emphasis Panel (ZRR1-RI-7 (02))
Program Officer
Gorospe, Rafael
Project Start
2001-09-30
Project End
2009-07-31
Budget Start
2004-09-27
Budget End
2005-07-31
Support Year
4
Fiscal Year
2004
Total Cost
$2,508,566
Indirect Cost
Name
University of Hawaii
Department
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Kaholokula, Joseph Keawe'aimoku; Antonio, Mapuana C K; Ing, Claire K Townsend et al. (2017) The effects of perceived racism on psychological distress mediated by venting and disengagement coping in Native Hawaiians. BMC Psychol 5:2
Yu, Xufen; Zhang, Mingming; Annamalai, Thirunavukkarasu et al. (2017) Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors. Eur J Med Chem 125:515-527
Jarvi, Susan I; Bianchi, Kiara R; Farias, Margaret Em et al. (2016) Characterization of class II ? chain major histocompatibility complex genes in a family of Hawaiian honeycreepers: 'amakihi (Hemignathus virens). Immunogenetics 68:461-475
Sun, Zuyue; Schriewer, Jill; Tang, Mingxin et al. (2016) The TGF-? pathway mediates doxorubicin effects on cardiac endothelial cells. J Mol Cell Cardiol 90:129-38
Youn, Ui Joung; Sripisut, Tawanun; Park, Eun-Jung et al. (2015) Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum. Bioorg Med Chem Lett 25:4719-23
Miklossy, Gabriella; Youn, Ui Joung; Yue, Peibin et al. (2015) Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin ?-2 Expression, and Induce Antitumor Effects against Human Glioma. J Med Chem 58:7734-48
Panee, Jun (2015) Potential Medicinal Application and Toxicity Evaluation of Extracts from Bamboo Plants. J Med Plant Res 9:681-692
Panee, Jun; Pang, Xiaosha; Munsaka, Sody et al. (2015) Independent and co-morbid HIV infection and Meth use disorders on oxidative stress markers in the cerebrospinal fluid and depressive symptoms. J Neuroimmune Pharmacol 10:111-21
Rueli, Rachel H L H; Parubrub, Arlene C; Dewing, Andrea S T et al. (2015) Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain. J Alzheimers Dis 44:379-83
Hamad, Mazen Lee; Engen, William; Morris, Kenneth R (2015) Impact of hydration state and molecular oxygen on the chemical stability of levothyroxine sodium. Pharm Dev Technol 20:314-9

Showing the most recent 10 out of 142 publications