This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Delaware INBRE Annual Progress Report (APR) 2007Grant No. 5P20RR016472-2007Undergraduate Research Experience CoreCore Directors:Ms. Jeanette Miller, DBI Assistant DirectorDr. Veronica Rempusheski, UD School of NursingCore Objective: To strengthen the biomedical research skills of undergraduates by involving them in faculty research.Summer Undergraduate Research InternshipsOverview: The Delaware INBRE grant supported twenty-seven undergraduate research interns in a ten-week program conducted June - August 2006. The program required students to work forty hours per week at their research assignments, and to prepare a poster or talk for an end of summer research symposium, hosted by the University of Delaware through a grant from the Howard Hughes Medical Institute. All INBRE students participated in a four-session seminar series on clinical and translational research and research ethics, hosted by INBRE partner Christiana Care Health System. Each student was also provided a stipend, housing allowance, and when needed, transportation to required events. A number of students continue their research projects during the academic year, and present at poster sessions at national meetings.Institutions Involved: All six Delaware INBRE partner institutions participated in the program, as host research sites or as a source of students. This year featured an increased number of cross-institutional assignments, with 40% of students conducting research at an institution other than their home institutions. During the placement process, students were asked to describe their areas of scientific interest, to review faculty research descriptions and to suggest up to four labs of interest throughout the INBRE network. Whenever possible, students were placed in one of their labs of choice. Some thirty network faculty were involved, either as research mentors or in selecting student participants from their respective institutions. For the second year, the group included nursing faculty and students from the University of Delaware and Wesley College. Jeanette Miller, Assistant Director, Delaware Biotechnology Institute provided student placement and program oversight. Student Data: The diverse student group included 60% women and 30% underrepresented students (five African-American and two Hispanic students). Interns were sophomores, juniors and seniors in life and health science majors, including biology, biotechnology, chemistry, electrical and computer engineering, and nursing. Research interns also included four students involved in the two-year histotechnician program at Delaware Technical & Community College. To be candidates for an internship, students were required to have a minimum GPA of 3.00.Program Evaluation: Interns completed evaluations at the conclusion of the internship. Students reported that the internship was a very positive experience, which in many instances confirmed or catalyzed a students interest in a biomedical research career. Students often reported that the internship developed or gave them confidence in some of their own skills: that they could function as a member of a lab team; that they could develop a deep understanding of a scientific project and talk about it to other scientists, which they had the opportunity to do at the end-of-summer research symposium. All INBRE students prepared scientific posters, and two INBRE students were invited to give symposium talks during the August 2006 capstone event. A long-term survey of Delaware BRIN/INBRE students is planned for spring 2007, to gather data on students continued educational and career choices, and the effect of the internship experience on this choice. INBRE students also present their research at other venues, including at the NIH NISBRE meeting, which took place in July 2006. Students are encouraged to apply to national meetings that host undergraduate researchers, such as the NIGMS Annual Biomedical Research Conference for Minority Students (ABRCMS). INBRE has assisted three students in attending this conference. Delaware INBRE Summer 2006 Undergraduate Research Intern ProjectsAnsbach, CatrinaFaculty Mentor - BrougherSurfactant Protein B Expression in Domestic Fowl EmbryosBarninger, DebraFaculty Mentor - HarringtonDegraduation of Genomic DNA from Helix apersaBates, TessaFaculty Mentors - Prettyman, WheelerGrandparents Knowledge of Grandchildrens Physical ActivityCallahan, StephanieFaculty Mentor - KmiecImpact of Msh2 Deficiency on Rad51 Foci Formation in Response to OligonucleotidesCriel, MichelleFaculty Mentors - Cannon, PolekYoung Couples Confronting Breast Cancer: Stress Related to Being a MomEdwards, JonathanFaculty Mentor - FurstGelation Kinetics of -Hairpin Oligopeptides Using Laser Tweezer MicrorheologyEngel, LioraFaculty Mentor - BaisRoot Secretion Mining for P. aeruginosa and E. faecalis Biofilm InhibitorsFeld, SamanthaFaculty Mentor - Cancer Center @ Christiana CareCorrelation of Preoperative FEV1 Values and Postoperative Hospital Stay Following Lung ResectionForstrom, RobertFaculty Mentor - SteinerA Virtual-Reality Approach for the Treatment ofJegede, YewandeFaculty Mentor - DiMariaIdentification of a Small Nucleolar RNA in MicrosporidiaJohnson, LauraSherrierIdentification of Nodulation Mutants in an EMS-mutagenized Population of Medicago truncatulaKell, CopelandFaculty Mentor - StoleruAlumina Nanofibers Generated Through a AnodizationKoyoshi, FumieFaculty Mentor - PolenovaAn Evaluation of Solvolytic Mechanisms at a Trigonal CarbonLavender, MarysolFaculty Mentor - UsherCholesterol Depletion in Adipocytes and its Affects on Lipoproteins E and C1Mancini, JohnFaculty Mentor - RobinsonTesting the Effect of DTT on the Unfolded Protein Response Mechanism in Saccharomyces cerevisiaeManrai, ArjunFaculty Mentor - KmiecAnalysis of the Targeted Gene Repair Transcriptome in Mammalian SystemsMills, TimothyFaculty Mentor - WommackBacterial Production in the Chesapeake and Delaware BaysMlynarski, StaceyFaculty Mentor - Fondong, VincentThe Gemini virus Coat Protein: Detection of mRNA and Subcellular LocalizationNiedermeyer, MonicaFaculty Mentor - BauerLung Cancer Screening Using Low-Dose CT  The Christiana Care ExperienceOmondi, ArnoldFaculty Mentor - DSouzaUse of LFERS to Evaluate the Solvolytic Mechanism of Isopropenyl ChloroformateOren, RachelFaculty Mentor - Cooper, Farach-CarsonTumor Necrosis Factor Alpha (TNF- ) Regulation of Reticulocalbin (RCN-1) cell surface expression and Capillary-like formation in Bone Marrow Endothelial Cells (BMECs)Palladino, GinaFaculty Mentor - LenhoffCrystallization and Aggregation of Soybean Trypsin Inhibitor at Low Salt Concentration: A Phase Behavior Study of Protein Salting InPomroy, DonnaFaculty Mentors - Schanen, Farach-CarsonThe Role of MeCP2 in Neuron Development and Bone HomesostasisScott, EvanFaculty Mentors - BauerEvaluation of Virtual Reality Bronchoscopy SimulationShankman, LauraFaculty Mentor - NaikNiobium-Doped Bismuth MolybdatesSnow, SamanthaFaculty Mentor - BrougherOntogeny of Surfactant Protein B (SP-B) Expression in Avian LungVasta, CaseyFaculty Mentor - KmiecssDNA Oligonucleotides Arrest Growth of Esophageal Cancer Cells

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