This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Epithelial ovarian cancer is an ovulation-related disease. It appears that genotoxic/mutagenic reactive oxygen species generated during the mechanics of follicular rupture damage the DNA of ovarian surface epithelial cells that survive the insult of ovulation; a cell that is not repaired or does not become committed to apoptosis (because of a defective tumor suppressor mechanism) is hence potentially problematic. Since the prognosis for ovarian cancer patients with metastatic disease is so poor, and early detection has proven elusive, it is imperative that prospective methods of chemoprevention be explored. The objectives of this subproject are to assess the etiological link between ovulation and carcinogenesis and to evaluate the prospective role of antioxidants (e.g., vitamin E) in ovarian cancer prophylaxis.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016474-06
Application #
7381593
Study Section
Special Emphasis Panel (ZRR1-RI-7 (02))
Project Start
2006-05-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
6
Fiscal Year
2006
Total Cost
$166,895
Indirect Cost
Name
University of Wyoming
Department
Type
Schools of Allied Health Profes
DUNS #
069690956
City
Laramie
State
WY
Country
United States
Zip Code
82071
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