This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this INBRE subproject is to determine the role of specific genes in cardiac hypertrophy in response to Angiotensin II during fetal heart development using control fed or nutrient restricted ewes. Postnatal obesity induced by prenatal undernutrition may lead to higher incidence of cardiovascular disease as adult. The ability of the fetus to communicate with the uterus and maintain pregnancy under nutritional stress is critical to its survival. Even if the fetus survives pregnancy, intra-uterine insults resulting from undernutrition or stress can re-program fetal growth and development such that post-natal health is compromised. Elucidation of molecular mechanisms involved in the regulation of fetal heart development is essential for understanding adult cardiovascular disease that results from 'programming events' during fetal development.
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