This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Genomics Facility at UMC is a training facility that provides access to specialized equipment typically, but not entirely, associated with microarray technology. The genomics facility is seeing steady usage. The most active pieces of equipment being used are the Agilent bioanalyzer (for DNA and RNA analyses), the ScanArray Express scanner (microarray analysis) and the adjoining analytical computer and programs. Numerous labs throughout the Medical Center avail themselves of the facility on a regular basis. The facility also scans slides for other labs within the state that are not in the metro Jackson area. Presently, we are scanning catfish microarrays for Dr. Larry Hansen?s lab at Mississippi State University. We continue to introduce and train new labs in microarray technology. Although several facility users applied for grants this past year none were received. However we continue to do feasibility studies with several other labs which we hope can be garnered into fundable proposals. A proposal to study epigenetic effects of alcohol on zebrafish will be submitted within the current funding period. We have also agreed to beta-test some microarrays made by the University of Toronto Health Science network and W.L. Gore and Associates. Additionally we continue to demonstrate to pathology residents how RNA is labeled, hybridized and analyzed. Dr. Warren May, a Biostatistician in the Department of Preventive Medicine works with most of the groups doing microarray analysis through the facility. We require all groups wanting to use the facility to consult with him about the design of their experiments before beginning. Users are also encouraged to consult and collaborate with Dr. Youping Deng who is the bioinformatics expert at the University of Southern Mississippi and co-director of the bioinformatics branch of the MFGN. It is the goal of this facility to help facilitate the enhancement of the quality and quantity of research and life science training within the state of Mississippi through being available to all student and faculty researchers within the state; to train them in the methods and use of all of the equipment within the facility for their research. The facility is supervised by the director and facility manager and is available to all users at virtually anytime.
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