This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Bioinformatics Core provides investigators at the lead and partner institutions access to bioinformatics analysis tools and expert assistance in utilizing these tools for data analysis and discovery. Access to Vector NTI is provided for gene sequence analysis. Analyses of gene expression data, including Ingenuity Pathways Analysis (IPA), are provided in conjunction with the Genomics Core and for expression results generated off-site. In addition, IPA access or analyses are provided to assist investigators in generation of hypotheses. WV-INBRE sponsors a Bioinformatics Workshop every summer for investigators at the partner and lead institutions. These workshops focus on methods and techniques relevant to the research projects supported by WV-INBRE and are presented by content experts, such as NIH-NCBI personnel and training staff for software supported by WV-INBRE. Bioinformatics Core personnel have developed courses on use of bioinformatics tools at the lead institutions and will assist partner institutions in developing courses or exercises to enhance existing courses.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016477-10
Application #
8167669
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2010-05-01
Project End
2011-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
10
Fiscal Year
2010
Total Cost
$131,987
Indirect Cost
Name
Marshall University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
036156615
City
Huntington
State
WV
Country
United States
Zip Code
25701
Zhang, Yu; Chen, Shiguo; Wei, Chaoyang et al. (2018) Dietary compound proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves attenuate chemotherapy-resistant ovarian cancer stem cell traits via targeting the Wnt/?-catenin signaling pathway and inducing G1 cell cycle arrest. Food Funct 9:525-533
Gao, Ying; Yin, Junfeng; Rankin, Gary O et al. (2018) Kaempferol Induces G2/M Cell Cycle Arrest via Checkpoint Kinase 2 and Promotes Apoptosis via Death Receptors in Human Ovarian Carcinoma A2780/CP70 Cells. Molecules 23:
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Zhang, Yu; Chen, Shiguo; Wei, Chaoyang et al. (2018) Dietary Compound Proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves inhibit angiogenesis and regulate cell cycle of cisplatin-resistant ovarian cancer cells via targeting Akt pathway. J Funct Foods 40:573-581
Jia, Ling-Yan; Wu, Xue-Jin; Gao, Ying et al. (2017) Inhibitory Effects of Total Triterpenoid Saponins Isolated from the Seeds of the Tea Plant (Camellia sinensis) on Human Ovarian Cancer Cells. Molecules 22:
Pan, Haibo; Wang, Fang; Rankin, Gary O et al. (2017) Inhibitory effect of black tea pigments, theaflavin?3/3'-gallate against cisplatin-resistant ovarian cancer cells by inducing apoptosis and G1 cell cycle arrest. Int J Oncol 51:1508-1520
Kocher, Caitlin; Christiansen, Matthew; Martin, Sarah et al. (2017) Sexual dimorphism in obesity-related genes in the epicardial fat during aging. J Physiol Biochem 73:215-224
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