This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major area of research undertaken in Dr. Telleria's laboratory deals with the molecular mechanisms by which steroid and peptide hormones control function, survival and physiological death (apoptosis) of ovarian cells. In vivo, ex-vivo and in-vitro experimental approaches are used combined with state-of-the-art techniques for the study of apoptosis and gene expression. The ultimate goal is to understand the mechanisms of ovarian cell death to be able to: i) reestablish function in cases of infertility caused by luteal dysfunction and corpus luteum inadequacy, in which the primary problem is the insufficient quantity or duration of progesterone secretion that leads to repetitive pregnancy losses; and ii) accelerate cell death in the case of ovarian cancer, which is the fourth most frequent cause of cancer death among women and the leading cause of death from gynecological malignancies.
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