Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
Specific Aim 1 : To solve a nonlinear differential equation with the changing boundary condition due to the dependency Rd = f(c), where c is a concentration of K+ ions near the outer membrane boundary, and Rd = dUw/dl is the differential resistance of the membrane at the point of the v.c.c. with voltage U and current I. As the result, we will obtain the development of the non-stability in time and space. Integrating the equation will make it possible to obtain the quantity of ions K+ that arrive at the axon due to one pulse. Experimental results: ~3.6xlO""""""""12 Mole/cm2/pulse. The determination of the non-stability in time (eq.16, [11]) will give the entire time of the growing part of the pulse. Experimental results: approximately 0.5 msec.
Specific Aim 2 : To describe the process of the nerve pulse transfer in a more complete way taking into account the sodium component of the membrane current. This component, as it is known, plays a very important role in the dynamics of the change in the membrane potential.
Specific Aim 3 : Further refinement of the theory.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016479-10
Application #
8168031
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2010-05-01
Project End
2011-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
10
Fiscal Year
2010
Total Cost
$20,568
Indirect Cost

  Institution

Name
University of South Dakota
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
929930808
City
Vermillion
State
SD
Country
United States
Zip Code
57069

  Publications

Anderson, Ruthellen H; Lensing, Cody J; Forred, Benjamin J et al. (2018) Differentiating Antiproliferative and Chemopreventive Modes of Activity for Electron-Deficient Aryl Isothiocyanates against Human MCF-7 Cells. ChemMedChem 13:1695-1710
Rozenblat, Vanja; Ong, Deborah; Fuller-Tyszkiewicz, Matthew et al. (2017) A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders. J Psychiatr Res 84:62-72
Oleas, Gabriela; Callegari, Eduardo; Sepúlveda, Romina et al. (2017) Heterologous expression, purification and characterization of three novel esterases secreted by the lignocellulolytic fungus Penicillium purpurogenum when grown on sugar beet pulp. Carbohydr Res 443-444:42-48
Herrera, Andrea L; Suso, Kuta; Allison, Stephanie et al. (2017) Binding host proteins to the M protein contributes to the mortality associated with influenza-Streptococcus pyogenes superinfections. Microbiology :
Oleas, Gabriela; Callegari, Eduardo; Sepulveda, Romina et al. (2016) Properties of Two Novel Esterases Identified from Culture Supernatant of Penicillium purpurogenum Grown on Sugar Beet Pulp. Insights Enzym Res 1:
Zhang, Lei; Hapon, Maria B; Goyeneche, Alicia A et al. (2016) Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors. Mol Oncol 10:1099-117
Callegari, Eduardo A (2016) Shotgun Proteomics Analysis of Estrogen Effects in the Uterus Using Two-Dimensional Liquid Chromatography and Tandem Mass Spectrometry. Methods Mol Biol 1366:131-148
Herrera, Andrea L; Huber, Victor C; Chaussee, Michael S (2016) The Association between Invasive Group A Streptococcal Diseases and Viral Respiratory Tract Infections. Front Microbiol 7:342
Bonilla, José Oscar; Callegari, Eduardo Alberto; Delfini, Claudio Daniel et al. (2016) Simultaneous chromate and sulfate removal by Streptomyces sp. MC1. Changes in intracellular protein profile induced by Cr(VI). J Basic Microbiol :
Zhang, Fan; Hartnett, Sigurd; Sample, Alex et al. (2016) High fat diet induced alterations of atrial electrical activities in mice. Am J Cardiovasc Dis 6:1-9

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