Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We continue investigating functions of apolipoprotein L1 (ApoL1) and ApoL2 in the induction of autophagy, a self-eating mechanism, in cancer cell death. Autophagy is normally used by cells to recycle the building blocks, such as amino acids, nucleic acids and fatty acids, for resynthesize macromolecules, such as proteins, DNA and RNA and lipids. Recent study also showed that autophagy can function as a programmed cell death mechanism to eliminate damaged cells. Our recent results showed that ApoL1 is one of the molecular regulators that induces autophagic cell death in various cancer cell types and its closely related protein ApoL2 can synergistically enhance ApoL1-induced cell death. Both ApoL1 and L2 are potential biomarkers for diagnosis, prognosis and treatment of human cancers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR016480-09
Application #
7960232
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2009-05-01
Project End
2010-02-28
Budget Start
2009-05-01
Budget End
2010-02-28
Support Year
9
Fiscal Year
2009
Total Cost
$96,544
Indirect Cost

  Institution

Name
New Mexico State University Las Cruces
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
173851965
City
Las Cruces
State
NM
Country
United States
Zip Code
88003

  Publications

Licon-Munoz, Yamhilette; Fordyce, Colleen A; Hayek, Summer Raines et al. (2018) V-ATPase-dependent repression of androgen receptor in prostate cancer cells. Oncotarget 9:28921-28934
Duplessis, Christopher; Gregory, Michael; Frey, Kenneth et al. (2018) Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis. J Intensive Care 6:72
Johnston, Robert K; Harper, Jason C; Tartis, Michaelann S (2017) Control over Silica Particle Growth and Particle-Biomolecule Interactions Facilitates Silica Encapsulation of Mammalian Cells with Thickness Control. ACS Biomater Sci Eng 3:2098-2109
Rossi, Shannan L; Tesh, Robert B; Azar, Sasha R et al. (2016) Characterization of a Novel Murine Model to Study Zika Virus. Am J Trop Med Hyg 94:1362-9
Shuster, Michele; Claussen, Kira; Locke, Melly et al. (2016) BIOINFORMATICS IN THE K-8 CLASSROOM: DESIGNING INNOVATIVE ACTIVITIES FOR TEACHER IMPLEMENTATION. Int J Des Learn 7:60-70
Tsalik, Ephraim L; Henao, Ricardo; Nichols, Marshall et al. (2016) Host gene expression classifiers diagnose acute respiratory illness etiology. Sci Transl Med 8:322ra11
Colip, Leslie; Burge, Mark R; Sandy, Phillip et al. (2016) Exercise Intervention Improves the Metabolic Profile and Body Composition of Southwestern American Indian Adolescents. J Diabetes Obes 3:
Reiss, Rebecca A; Guerra, Peter; Makhnin, Oleg (2016) Metagenome phylogenetic profiling of microbial community evolution in a tetrachloroethene-contaminated aquifer responding to enhanced reductive dechlorination protocols. Stand Genomic Sci 11:88
Camacho, Jenny E; Shah, Vallabh O; Schrader, Ronald et al. (2016) PERFORMANCE OF A1C VERSUS OGTT FOR THE DIAGNOSIS OF PREDIABETES IN A COMMUNITY-BASED SCREENING. Endocr Pract 22:1288-1295
Andrade, C C; Young, K I; Johnson, W L et al. (2016) Rise and fall of vector infectivity during sequential strain displacements by mosquito-borne dengue virus. J Evol Biol 29:2205-2218

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