Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator. The purpose of this core is to provide neonatal myocyte cultures for COBRE researchers. Neonatal cultures are available on a routine schedule for all COBRE projects and several other projects by CRI faculty. The Cell Culture Core also isolates adult mouse cardiac myocytes, providing these cultures on demand. culture method here. We anticipate that this will provide important new avenues for CRI and COBRE investigators to develop more mechanistic approaches using their transgenic mouse lines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR017662-06A1
Application #
7720645
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-07-01
Project End
2009-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
6
Fiscal Year
2008
Total Cost
$188,785
Indirect Cost

  Institution

Name
University of South Dakota
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
929930808
City
Vermillion
State
SD
Country
United States
Zip Code
57069

  Publications

O'Connell, Timothy D; Block, Robert C; Huang, Shue P et al. (2017) ?3-Polyunsaturated fatty acids for heart failure: Effects of dose on efficacy and novel signaling through free fatty acid receptor 4. J Mol Cell Cardiol 103:74-92
Eclov, Julie A; Qian, Qingwen; Redetzke, Rebecca et al. (2015) EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4. J Lipid Res 56:2297-308
Savinova, Olga V; Fillaus, Kristi; Harris, William S et al. (2015) Effects of niacin and omega-3 fatty acids on the apolipoproteins in overweight patients with elevated triglycerides and reduced HDL cholesterol. Atherosclerosis 240:520-5
McKenzie, Casey W; Craige, Branch; Kroeger, Tiffany V et al. (2015) CFAP54 is required for proper ciliary motility and assembly of the central pair apparatus in mice. Mol Biol Cell 26:3140-9
Kobayashi, Satoru; Liang, Qiangrong (2015) Autophagy and mitophagy in diabetic cardiomyopathy. Biochim Biophys Acta 1852:252-61
Jensen, Brian C; O?Connell, Timothy D; Simpson, Paul C (2014) Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation. J Cardiovasc Pharmacol 63:291-301
Wu, Steven C; Dahl, Erika F; Wright, Casey D et al. (2014) Nuclear localization of a1A-adrenergic receptors is required for signaling in cardiac myocytes: an “inside-out” a1-AR signaling pathway. J Am Heart Assoc 3:e000145
O'Connell, Timothy D; Jensen, Brian C; Baker, Anthony J et al. (2014) Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance. Pharmacol Rev 66:308-33
Savinova, Olga V; Fillaus, Kristi; Jing, Linhong et al. (2014) Reduced apolipoprotein glycosylation in patients with the metabolic syndrome. PLoS One 9:e104833
Xu, Xianmin; Kobayashi, Satoru; Chen, Kai et al. (2013) Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes. J Biol Chem 288:18077-92

Showing the most recent 10 out of 65 publications