The CEHS was established in 2000 with the goal of developing a nationally competitive research program to study the mechanism of human disease and environmental impacts on human disease. In order to achieve this goal three focus areas of research were selected in order to facilitate the development of a critical mass of investigators in each area and on the basis of national need and expertise within the existing faculty. These focus areas are respiratory/immunotoxicology, neurotoxicology, and genetic and cardiovascular toxicology. With the aid of startup support five talented new faculty were hired and a sixth is being recruited. State-of-the-art core facilities were established and a strong mentoring program was put into place. This COBRE application is an ideal fit to develop the new faculty, hire additional faculty to further enhance the existing faculty and to enhance the support network and the infrastructure to develop the CEHS to a nationally competitive center.
The specific aims of this application are:
Aim 1 Promote the development of six talented faculty through the support of individual sub-projects Aim 2 Enhance the critical mass of competitive CEHS investigators at the UM through strategic recruitment of four new faculty.
Aim 3 Establish a support network for CEHS investigators that promotes infrastructure development, collaborative interaction and facilitate mentoring.
Aim 4 Enhance the infrastructure for CEHS research through the acquisition of critically needed instrumentation for a shared ICPMS and Flow Cytometer; and improve facilities, i.e., clean room for ICPMS, tissue culture, small animal surgery and a bioinformatics and computational core facility. We propose that with the achievement of these specific aims that all of the investigators supported by this COBRE grant will move into R01 funding and that the an overall research environment will have been created so that the CEHS investigators will be able to obtain a NIEHS center grant, a Ph.D. training grant from the NIEHS and program project grant support.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-A (02))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Montana
Other Health Professions
Schools of Pharmacy
United States
Zip Code
Peters, Bridget; Ballmann, Christopher; Quindry, Tiffany et al. (2018) Experimental Woodsmoke Exposure During Exercise and Blood Oxidative Stress. J Occup Environ Med 60:1073-1081
Ward, Tony J; Semmens, Erin O; Weiler, Emily et al. (2017) Efficacy of interventions targeting household air pollution from residential wood stoves. J Expo Sci Environ Epidemiol 27:64-71
Biswas, Rupa; Trout, Kevin L; Jessop, Forrest et al. (2017) Imipramine blocks acute silicosis in a mouse model. Part Fibre Toxicol 14:36
Sanchez-Contreras, Monica; Cardozo-Pelaez, Fernando (2017) Age-related length variability of polymorphic CAG repeats. DNA Repair (Amst) 49:26-32
Ferguson, Matthew D; Semmens, Erin O; Weiler, Emily et al. (2017) Lung function measures following simulated wildland firefighter exposures. J Occup Environ Hyg 14:739-748
Park, Sunyoung; Nevin, Andrew B C; Cardozo-Pelaez, Fernando et al. (2016) Pb exposure prolongs the time period for postnatal transient uptake of 5-HT by murine LSO neurons. Neurotoxicology 57:258-269
Jessop, Forrest; Hamilton, Raymond F; Rhoderick, Joseph F et al. (2016) Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure. Toxicol Appl Pharmacol 309:101-10
Gábriel, Robert; Erdélyi, Ferenc; Szabó, Gábor et al. (2016) Ectopic transgene expression in the retina of four transgenic mouse lines. Brain Struct Funct 221:3729-41
Wang, Xiaobo; Olson, Jenessa R; Rasoloson, Dominique et al. (2016) Dynein light chain DLC-1 promotes localization and function of the PUF protein FBF-2 in germline progenitor cells. Development 143:4643-4653
Yi, Feng; DeCan, Evan; Stoll, Kurt et al. (2015) Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures. Epilepsia 56:297-309

Showing the most recent 10 out of 161 publications