This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Type I cells of the carotid body (CB) are chemoreceptors that sense changes in blood pH, CO2, and O2. These cells respond to stimulation with a membrane depolarization that induces Ca2+ entry through voltage-dependent Ca2+ channels and the subsequent release of a neurotransmitter that activates the afferent fibers of the carotid sinus nerve. In the case of hypoxia, the cause of membrane depolarization seems to be the inhibition of K+ channels. Three different types of O2-sensitive K+ channels have been postulated to elicit such depolarization: a voltage-gated channel in rabbit type I cells and a large-conductance Ca2+ - dependent K+ channel (maxiK) and a TASK-like channel in rat type I cells.
The specific aim of this project will be to identify a putative membrane-bound hemoproteic sensor in type I cells of the carotid body (CB), and determine how this molecule interacts with O2-sensitive K+ channels to alter channel activity and confer hypoxic sensitivity to type I cells of the CB.
Showing the most recent 10 out of 177 publications