This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.DESCRIPTION (provided by applicant): The MUSC is an emerging center of excellence in biomedical research with a few key areas of exceptional strength upon which it can build future growth and development. One of these areas is based on the study of bioactive lipids, their structure, metabolism, and function. The scope of this field of research and its development at MUSC allow a transition to global studies on bioactive lipids (designated herein as Lipidomics) and their contribution to mammalian pathophysiology. Thus, the organizing hypothesis of this COBRE states that the diversity of bioactive lipids provides a rich network of pathways that regulate cell function. Perturbations of these pathways contribute to important pathobiologic processes such as cancer progression, metastasis, aging, and fungal pathogenesis. The specific goal of this proposal is to develop an interactive Center of Lipidomics and Pathobiology that will promote the growth and excellence of research at MUSC. This will be achieved by pursuing the following specific aims (1) Mentor an initial group of five targeted junior investigators to develop independent NIH-funded research; (2) Develop novel and critical scientific cores; (3) Recruit additional independent investigators with key expertise; (4) Sustain the growth of the COBRE through the development of specific program projects. These activities should result in a highly developed Center with a critical mass of biomedical excellence in an evolving area of research highly significant to cancer biology, aging, inflammation, and infectious diseases.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR017677-06
Application #
7610437
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2007-08-01
Project End
2008-06-30
Budget Start
2007-08-01
Budget End
2008-06-30
Support Year
6
Fiscal Year
2007
Total Cost
$251,127
Indirect Cost
Name
Medical University of South Carolina
Department
Biochemistry
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
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