Abstract

Core C will support the establishment and maintenance of the COBRE Gene Array Core facility. The Core will provide the interface, expertise, training and mentoring in gene array analysis necessary for the advancement of COBRE projects on different epithelia including Project 1: """"""""Transepithelial ion transport and its regulation"""""""" (renal collecting ducts and vas deference), Project 2: """"""""Intestinal epithelial migration: NSAID, polyamine-depletion, and depolarized membrane potential"""""""" (equine intestinal epithelia), and Project 3: """"""""Molecular basis of protein and vesicle traffic in epithelia"""""""" (pancreatic acinar cells and renal proximal tubules). These projects depend critically on comparisons in gene expression between different experimental conditions. The Core will provide gene array processing by outsourcing to other facilities in conjunction with a local analysis facilities to process the data. This analysis facility in conjunction with the provided expertise, training and mentoring will enable COBRE investigators to establish themselves through advancing their research on epithelia in health and disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
1P20RR017686-01
Application #
6691449
Study Section
Special Emphasis Panel (ZRR1)
Project Start
2002-09-30
Project End
2007-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Kansas State University
Department
Type
DUNS #
City
Manhattan
State
KS
Country
United States
Zip Code
66506

  Publications

Ishiguro, Susumu; Kawabata, Atsushi; Zulbaran-Rojas, Alejandro et al. (2018) Co-treatment with a C1B5 peptide of protein kinase C? and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation. Biochem Biophys Res Commun 495:962-968
Kudo, Takayuki; Wangemann, Philine; Marcus, Daniel C (2018) Claudin expression during early postnatal development of the murine cochlea. BMC Physiol 18:1
Paper, Janet M; Mukherjee, Thiya; Schrick, Kathrin (2018) Bioorthogonal click chemistry for fluorescence imaging of choline phospholipids in plants. Plant Methods 14:31
Honda, Keiji; Kim, Sung Huhn; Kelly, Michael C et al. (2017) Molecular architecture underlying fluid absorption by the developing inner ear. Elife 6:
Liu, Qinfang; Miller, Laura C; Blecha, Frank et al. (2017) Reduction of infection by inhibiting mTOR pathway is associated with reversed repression of type I interferon by porcine reproductive and respiratory syndrome virus. J Gen Virol 98:1316-1328
Miyazaki, Hiromitsu; Wangemann, Philine; Marcus, Daniel C (2016) The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion. BMC Physiol 17:1
Krishnamoorthy, Gayathri; Reimann, Katrin; Wangemann, Philine (2016) Ryanodine-induced vasoconstriction of the gerbil spiral modiolar artery depends on the Ca(2+) sensitivity but not on Ca(2+) sparks or BK channels. BMC Physiol 16:6
Montero-Astúa, Mauricio; Ullman, Diane E; Whitfield, Anna E (2016) Salivary gland morphology, tissue tropism and the progression of tospovirus infection in Frankliniella occidentalis. Virology 493:39-51
Dib, Lea H; Ortega, M Teresa; Melgarejo, Tonatiuh et al. (2016) Establishment and characterization of DB-1: a leptin receptor-deficient murine macrophage cell line. Cytotechnology 68:921-33
Ohta, Naomi; Ishiguro, Susumu; Kawabata, Atsushi et al. (2015) Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes. PLoS One 10:e0123756

Showing the most recent 10 out of 206 publications