This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The object of this COBRE project is to design BCG vaccines that target TuAg1 (CD155) and MUC1. Theme A: Significance of Fetal Protein and Phenotypes in Cancer Novel Hepatocellular Vaccines Targeting Rat CD155 and MUC1 This research is focused on the development of novel vaccines for the prevention and/or treatment of cancer. The objective of this project is to develop innovative cancer vaccines that may be useful in the management of patients at risk for, or with ,hepatocellular carcinoma. Hepatocellular carcinoma is a leading cause of cancer mortality worldwide and frequently develops in patients with liver cirrhosis secondary to alcohol abuse or viral infections. Her vaccine uses BCG that have been genetically altered to express interleukin-2 and TuAg1, a tumor associated antigen over-expressed in hepatocellular carcinoma

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017695-05
Application #
7381873
Study Section
Special Emphasis Panel (ZRR1-RI-A (02))
Project Start
2006-07-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
5
Fiscal Year
2006
Total Cost
$24,331
Indirect Cost
Name
Rhode Island Hospital
Department
Type
DUNS #
075710996
City
Providence
State
RI
Country
United States
Zip Code
02903
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