This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: We hypothesize that the oncogenic potential of aberrant elevated La protein overstimulates cyclin D1 protein expression and cell proliferation, a hallmark of tumorigenesis in oral cancer. Significance: The poor survival rate of oral cancer patients underscores the need of novel anti-cancer strategies. We propose a novel cellular mechanism, which is a likely contributing factor in oral cancer progression. New insight into the mechanism of cyclin D1 overexpression leads to novel therapeutic interventions, which would be beneficial for many oral cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017696-08
Application #
7959786
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2009-06-01
Project End
2010-05-31
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
8
Fiscal Year
2009
Total Cost
$7,108
Indirect Cost
Name
Medical University of South Carolina
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Yuen, Hon K (2018) Factors associated with additional time dental hygienists spent on educating patients with diabetes. Spec Care Dentist 38:313-318
Heise, Tilman; Kota, Venkatesh; Brock, Alexander et al. (2016) The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2. Oncotarget 7:29664-76
Sabatini, Camila; Mennito, Anthony S; Wolf, Bethany J et al. (2015) Incorporation of bactericidal poly-acrylic acid modified copper iodide particles into adhesive resins. J Dent 43:546-55
Wood, James S; Marlow, Nicole M; Cayouette, Monica J (2015) Accuracy of dental torque wrenches. Gen Dent 63:e20-2
Shi, Changcheng; Cisewski, Sarah E; Bell, P Darwin et al. (2014) Measurement of three-dimensional anisotropic diffusion by multiphoton fluorescence recovery after photobleaching. Ann Biomed Eng 42:555-65
Qin, Tingting; Matmati, Nabil; Tsoi, Lam C et al. (2014) Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network. Nucleic Acids Res 42:e138
Yuen, H K; Hant, F N; Hatfield, C et al. (2014) Factors associated with oral hygiene practices among adults with systemic sclerosis. Int J Dent Hyg 12:180-6
Miller Jr, Preston D; McEntire, Mark L; Marlow, Nicole M et al. (2014) An evidenced-based scoring index to determine the periodontal prognosis on molars. J Periodontol 85:214-25
Yuen, Hon K; Nelson, Sybil L (2014) Test--retest reliability of Oral Health Impact Profile (OHIP-49) in adults with systemic sclerosis. Spec Care Dentist 34:27-33
Hill, E G; Slate, E H (2014) A SEMI-PARAMETRIC BAYESIAN MODEL OF INTER- AND INTRA-EXAMINER AGREEMENT FOR PERIODONTAL PROBING DEPTH. Ann Appl Stat 8:331-351

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