This proposal is to establish a Center of Biomedical Research Excellence (COBRE) on the Pathophysiology of neurodegenerative diseases at the University of North Dakota. The overall objective of this Center is to characterize the cellular mechanisms that contribute to neuronal degeneration. The proposed Center will consist of five projects involving 6 junior faculty members, each of which examines a unique aspect of the neurodegenerative process. These five projects, together with the proposed core facilities, faculty recruitments and administrative core will greatly assist us in meeting our long term goal: To develop a highly interactive and collaborative research group focused on understanding the etiology of neurodegeneration and developing therapeutic approaches to prevent or halt neuropathology.
The Specific Aims of this COBRE are: 1.) To develop successful independent research projects for the COBRE project directors that will enable them to obtain extramural R01 research grants. 2.) To enhance research infrastructure at the University of North Dakota School of Medicine & Health Sciences (UNDSMHS) through the development of core facilities to support all investigators. 3.) To expand biomedical faculty research in the area of neuroscience through the recruitment of an established senior level neuroscientist and four junior faculty members to UNDSMHS whose research is in the theme of our COBRE. These new faculty recruits will establish a critical mass of researchers at UNDSMHS whose areas of research expertise are in complimentary areas of neuroscience. 4.) To establish a nationally and internationally recognized Center of Neuroscience Research Excellence at the University of North Dakota. The successful completion of COBRE Specific Aims will establish a reputation at UNDSMHS as a Center of Neuroscience Research Excellence that will attract faculty, postdoctoral fellows, and graduate students interested in neuroscience research. Our Center will then be highly competitive for obtaining training grants, program project grants and center grants that will allow for the continuation of the Center of Neuroscience Research Excellence beyond the COBRE award.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017699-02
Application #
6658175
Study Section
Special Emphasis Panel (ZRR1-RI-A (01))
Program Officer
Gorospe, Rafael
Project Start
2002-09-15
Project End
2007-06-30
Budget Start
2003-09-01
Budget End
2004-06-30
Support Year
2
Fiscal Year
2003
Total Cost
$1,992,912
Indirect Cost
Name
University of North Dakota
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
102280781
City
Grand Forks
State
ND
Country
United States
Zip Code
58202
Kulas, Joshua A; Puig, Kendra L; Combs, Colin K (2017) Amyloid precursor protein in pancreatic islets. J Endocrinol 235:49-67
Krout, Danielle; Pramod, Akula Bala; Dahal, Rejwi Acharya et al. (2017) Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs. Biochem Pharmacol 142:204-215
Sukumaran, Pramod; Schaar, Anne; Sun, Yuyang et al. (2016) Functional role of TRP channels in modulating ER stress and Autophagy. Cell Calcium 60:123-32
Puig, Kendra L; Kulas, Joshua A; Franklin, Whitney et al. (2016) The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice. Neurobiol Aging 40:22-40
Liu, Qing Yan; Koukiekolo, Roger; Zhang, Dong Ling et al. (2016) Molecular events linking cholesterol to Alzheimer's disease and inclusion body myositis in a rabbit model. Am J Neurodegener Dis 5:74-84
Moritz, Amy E; Rastedt, Danielle E; Stanislowski, Daniel J et al. (2015) Reciprocal Phosphorylation and Palmitoylation Control Dopamine Transporter Kinetics. J Biol Chem 290:29095-105
Zhou, Xikun; Ye, Yan; Sun, Yuyang et al. (2015) Transient Receptor Potential Channel 1 Deficiency Impairs Host Defense and Proinflammatory Responses to Bacterial Infection by Regulating Protein Kinase C? Signaling. Mol Cell Biol 35:2729-39
Zhang, Shuang; Yu, Min; Guo, Qiang et al. (2015) Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway. Sci Rep 5:15859
Puig, Kendra L; Lutz, Brianna M; Urquhart, Siri A et al. (2015) Overexpression of mutant amyloid-? protein precursor and presenilin 1 modulates enteric nervous system. J Alzheimers Dis 44:1263-78
Rojanathammanee, Lalida; Floden, Angela M; Manocha, Gunjan D et al. (2015) Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. J Neuroinflammation 12:42

Showing the most recent 10 out of 178 publications