This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. X-ray crystallography is the most powerful tool in the determination of the three-dimensional structure of proteins, and in the elucidation of their structure-function relationships and their interactions with other macromolecules as well as small molecule ligands including drugs. The major aim of Core B is to establish, equip and staff with an experienced Director a Protein Structure Laboratory (PSL) built around state-of-the-art x-ray crystallography instrumentation to support the research community of the state of Kansas. Our facilities include a high brilliance RUH3R X-ray generator, Raxis IV++ imaging plate and an Xtream 2000 cryocooling system. We currently provide access of X-ray beam to a number of crystallographers. We also provide crystallographers and non-crystallographers services involving protein crystallization, X-ray diffraction data collection, phase determination, model building and crystallographic refinement, as well as help with grant application and writing publications.
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