This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The overall goal of the proposed COBRE program is to establish a multidisciplinary research center focused on the use of the best experimental strategies available to probe the structural and functional properties of targeted proteins. The Center will provide intensive mentoring and superb research environments to enhance the competitiveness of several junior faculty working at the interface of protein chemistry and biology at University of Kansas in Lawrence (KU-L), University of Kansas Medical Center in Kansas City (KUMC), Kansas State University in Manhattan (KSU), and Wichita State University in Wichita (WSU). Participating faculty are based in a variety of departments, but they all share a strong interest in understanding the relationship between the structure of a specific protein and its functional role in the biology of the cell. The expertise represented by both the junior faculty participants and the senior mentoring faculty spans a broad range from mass spectrometry and protein crystallography to microbial pathogenesis and regulation of cell differentiation. However, all participants are united by a strong desire to apply effective modern technologies and experimental strategies to the characterization of important proteins.
Our specific aims are:
Aim 1. To establish a Center of Biomedical Research Excellence in Protein Structure and Function that will synergize with other regional efforts in proteomics and protein chemistry and biology.
Aim 2. To organize a core of well-established, NIH-funded faculty members across the four institutions who will serve as mentors for recently hired and to-be-hired faculty in the area of protein structure and function, and to support 5 6 independent research programs of junior faculty addressing significant problems in protein structure and function from a biological as well as chemical perspective in an integrated, multidisciplinary way. Over the 5-year period the COBRE program will assist at least 15 new faculty in developing highly competitive research programs in protein structure and function.
Aim 3. To enhance the overall infrastructure for state-of-the-art research in protein structure and function through establishment of scientific cores that provides expertise and instrumentation in support of research in protein structure and function.
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