This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of the COBRE in Molecular Targets Molecular Modeling Core Facility have not changed. The Molecular Modeling Core Facility, operated by Dr. John Trent, is a state-of-the-art molecular modeling facility that has the capability of providing models based on structural data obtained from either X-ray crystallographic or NMR studies. In particular, this facility has provided important molecular modeling services for Projects I, II, III, and IV. Using homology modeling and virtual screening of potential inhibitors, Dr. Trent has made very important contributions on a collaborative basis to members of each MT-COBRE project. This facility is located within the Brown Cancer Center. The capabilities of the facility include techniques such as explicitly solvated molecular dynamics, homology modeling, docking, virtual screening, ESP calculations, and conformational searching.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR018733-04
Application #
7382008
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2006-07-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
4
Fiscal Year
2006
Total Cost
$110,670
Indirect Cost
Name
University of Louisville
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Neely, Aaron M; Zhao, Guoping; Schwarzer, Christian et al. (2018) N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts. Cell Microbiol 20:
Schmidt, M Lee; Hobbing, Katharine R; Donninger, Howard et al. (2018) RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis. Cancer Res 78:2614-2623
Garbett, Nichola C; Brock, Guy N; Chaires, Jonathan B et al. (2017) Characterization and classification of lupus patients based on plasma thermograms. PLoS One 12:e0186398
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Zhao, Guoping; Neely, Aaron M; Schwarzer, Christian et al. (2016) N-(3-oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins. Oncotarget 7:5924-42
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Lanceta, Lilibeth; Mattingly, Jacob M; Li, Chi et al. (2015) How Heme Oxygenase-1 Prevents Heme-Induced Cell Death. PLoS One 10:e0134144
Schwarzer, Christian; Fu, Zhu; Morita, Takeshi et al. (2015) Paraoxonase 2 serves a proapopotic function in mouse and human cells in response to the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-homoserine lactone. J Biol Chem 290:7247-58
Donninger, Howard; Calvisi, Diego F; Barnoud, Thibaut et al. (2015) NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2. J Cell Biol 208:777-89

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