This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many existing and emerging pathogens are multi-host pathogens that cross into human populations. It is difficult to predict how those pathogens will spread, because each species can have very different infectivity, immune response and ecological characteristics. The proposed research uses an innovative and powerful modeling approach that combines biological theory, published data and computer simulations to predict immune response, viral dynamics and epidemic spread from host mass. The research focuses on West Nile Virus (WNV), a pathogen that has spread rapidly across the US with severe consequences to human health. Because WNV is well-studied in the laboratory and in ecological field studies, there is sufficient information to build accurate computer models and to test their predictions. The models predict how WNV spreads within and between bird host species using Metabolic Scaling Theory (MST). MST identifies profound and predictable differences in the physiology, life history and ecology of different species based on their mass.
The aims of this project are to predict 1) the time course of viremia in each infective bird species 2) characteristics of bird species that harbor sufficient WNV to infect mosquito vectors, 3) how long those bird species are infective, and 4) which bird communities have a combination of species that enable WNV to persist. MST guides these predictions by relating rates of viral replication, immune response and ecological interaction to mass.
Aim 1 predicts the time course of viremia, including the concentration of virus in blood each day post infection and the duration of viremia that is sufficient to infect mosquito vectors. The duration of infective viremia is an important determinant of epidemic spread which is modeled in Aim 2.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR018754-07
Application #
8168270
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Project Start
2010-06-01
Project End
2011-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
7
Fiscal Year
2010
Total Cost
$384,436
Indirect Cost
Name
University of New Mexico
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
868853094
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Swanteson-Franz, Rachel J; Marquez, Destinie A; Goldstein, Craig I et al. (2018) New hairworm (Nematomorpha, Gordiida) species described from the Arizona Madrean Sky Islands. Zookeys :131-145
Banerjee, Soumya; Perelson, Alan S; Moses, Melanie (2017) Modelling the effects of phylogeny and body size on within-host pathogen replication and immune response. J R Soc Interface 14:
Gunning, Christian E; Ferrari, Matthew J; Erhardt, Erik B et al. (2017) Evidence of cryptic incidence in childhood diseases. Proc Biol Sci 284:
Brant, Sara V; Loker, Eric S; Casalins, Laura et al. (2017) Phylogenetic Placement of a Schistosome from an Unusual Marine Snail Host, the False Limpet (Siphonaria lessoni) and Gulls (Larus dominicanus) from Argentina with a Brief Review of Marine Schistosomes from Snails. J Parasitol 103:75-82
Hoard, Brittany; Jacobson, Bruna; Manavi, Kasra et al. (2016) Extending rule-based methods to model molecular geometry and 3D model resolution. BMC Syst Biol 10 Suppl 2:48
Hanson, David T; Stutz, Samantha S; Boyer, John S (2016) Why small fluxes matter: the case and approaches for improving measurements of photosynthesis and (photo)respiration. J Exp Bot 67:3027-39
Zhou, Peng; Tachedjian, Mary; Wynne, James W et al. (2016) Contraction of the type I IFN locus and unusual constitutive expression of IFN-? in bats. Proc Natl Acad Sci U S A 113:2696-701
Ernst, Crystal M; Hanelt, Ben; Buddle, Christopher M (2016) Parasitism of Ground Beetles (Coleoptera: Carabidae) by a New Species of Hairworm (Nematomorpha: Gordiida) in Arctic Canada. J Parasitol 102:327-35
Peña, Janeth J; Adema, Coen M (2016) The Planorbid Snail Biomphalaria glabrata Expresses a Hemocyanin-Like Sequence in the Albumen Gland. PLoS One 11:e0168665
Ng, Justin H J; Tachedjian, Mary; Deakin, Janine et al. (2016) Evolution and comparative analysis of the bat MHC-I region. Sci Rep 6:21256

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