The Oklahoma Medical Research Foundation (OMRF) herein proposes a site for a Center for Biomedical Research Excellence (COBRE) on 'Molecular Mechanisms and Genetics of Autoimmunity.' Research programs in immunology and rheumatic diseases were initiated over 20 years ago at the OMRF and have been steadily growing since. The faculty is responsible for a number of seminal discoveries and has made this an area of research excellence at the OMRF upon which to build this COBRE. We propose four Junior Investigators who have promising futures for biomedical research productivity in the genetics and molecular mechanisms of autoimmunity. Indeed, their projects should have an important impact upon our understanding of important autoimmune disease problems. These Junior Investigators are supported by eight exceptional Mentors, who will provide the guidance and advocacy so important for launching the successful careers of independent scientists. The projects proposed by the Junior Investigators will also be facilitated by a Nucleic Acid Analysis Core and a Data Analysis Core, both of which are directed by very experienced and knowledgeable staff scientists. Indeed, these cores will help efficiently and economically apply the most sophisticated technologies and methods to the problems being addressed in the projects performed by the Junior Investigators. Additional COBRE Junior Investigators will be recruited to this center making this a transitional mechanism for the development of many independent investigators, thereby sustaining the level of excellence now achieved in research into autoimmunity in Oklahoma. The synergies, collaborations, and directed effort of the COBRE will provide a much deeper level of understanding to human autoimmune diseases and will foster the independent career development of a strong group of Junior Investigators.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR020143-02
Application #
7171330
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2005-07-01
Project End
2006-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
2
Fiscal Year
2005
Total Cost
$268,506
Indirect Cost
Name
Oklahoma Medical Research Foundation
Department
Type
DUNS #
077333797
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
Deng, Yun; Zhao, Jian; Sakurai, Daisuke et al. (2016) Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Ann Rheum Dis 75:2007-2013
Zhao, Jian; Giles, Brendan M; Taylor, Rhonda L et al. (2016) Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Ann Rheum Dis 75:242-52
Liu, Ke; Kurien, Biji T; Zimmerman, Sarah L et al. (2016) X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome. Arthritis Rheumatol 68:1290-1300
Zhao, Jian; Wu, Hui; Langefeld, Carl D et al. (2015) Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. Clin Immunol 161:157-62
Dozmorov, Mikhail G; Dominguez, Nicolas; Bean, Krista et al. (2015) B-Cell and Monocyte Contribution to Systemic Lupus Erythematosus Identified by Cell-Type-Specific Differential Expression Analysis in RNA-Seq Data. Bioinform Biol Insights 9:11-9
Kariuki, S N; Ghodke-Puranik, Y; Dorschner, J M et al. (2015) Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. Genes Immun 16:15-23
Lu, Xiaoming; Zoller, Erin E; Weirauch, Matthew T et al. (2015) Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression. Am J Hum Genet 96:731-9
Kottyan, Leah C; Zoller, Erin E; Bene, Jessica et al. (2015) The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Hum Mol Genet 24:582-96
Armstrong, D L; Zidovetzki, R; Alarcón-Riquelme, M E et al. (2014) GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. Genes Immun 15:347-54
Morris, D L; Fernando, M M A; Taylor, K E et al. (2014) MHC associations with clinical and autoantibody manifestations in European SLE. Genes Immun 15:210-7

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