Abstract

The funds requested for the Nonhuman Primate and Laboratory core are to support highly integrated clinical management and laboratory investigations to project leaders and individual investigators. The animal and laboratory core will purchase, house and care for the macaques used in the two projects (M. Orandle and C. Apetrei) supported by this core. The core will be responsible for the daily clinical care of nonhuman primates and procedures such as inoculating the animals with virus, blood draws, intestinal biopsies, etc. The laboratory component of the core will perform hematology and clinical chemistry on peripheral blood, flow cytometry for quantitation of lymphocyte cell types (CD3, CD4,CD8) and immunologic assays including quantitation of CD8 T Cell responses using tetramer technology and intracellular cytokine stain. The core will also perform routine bacterial cultures, SIV isolation and quantitation, and pathologic examination of all necropsies and biopsies performed on animals utilized in these studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
1P20RR020159-01
Application #
6972196
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2004-07-01
Project End
2005-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$533,724
Indirect Cost

  Institution

Name
Louisiana State University A&M Col Baton Rouge
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803

  Publications

Crossland, Nicholas A; Alvarez, Xavier; Embers, Monica E (2018) Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques. Am J Pathol 188:672-682
Cheemarla, Nagarjuna R; Baños-Lara, Ma Del Rocío; Naidu, Shan et al. (2017) Neutrophils regulate the lung inflammatory response via ?? T cell infiltration in an experimental mouse model of human metapneumovirus infection. J Leukoc Biol 101:1383-1392
Cai, S; Batra, S; Del Piero, F et al. (2016) NLRP12 modulates host defense through IL-17A-CXCL1 axis. Mucosal Immunol 9:503-14
Cai, S; Batra, S; Langohr, I et al. (2016) IFN-? induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense. Mucosal Immunol 9:718-29
Phillips, Bonnie L; Mehra, Smriti; Ahsan, Muhammad H et al. (2015) LAG3 expression in active Mycobacterium tuberculosis infections. Am J Pathol 185:820-33
Pahar, Bapi; Pan, Diganta; Lala, Wendy et al. (2015) Transforming growth factor-?1 regulated phosphorylated AKT and interferon gamma expressions are associated with epithelial cell survival in rhesus macaque colon explants. Clin Immunol 158:8-18
Gautam, Uma Shankar; Mehra, Smriti; Kaushal, Deepak (2015) In-Vivo Gene Signatures of Mycobacterium tuberculosis in C3HeB/FeJ Mice. PLoS One 10:e0135208
Mehra, Smriti; Foreman, Taylor W; Didier, Peter J et al. (2015) The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence. Am J Respir Crit Care Med 191:1185-96
Baños-Lara, Ma Del Rocío; Harvey, Lindsey; Mendoza, Alexander et al. (2015) Impact and regulation of lambda interferon response in human metapneumovirus infection. J Virol 89:730-42
Caskey, John R; Embers, Monica E (2015) Persister Development by Borrelia burgdorferi Populations In Vitro. Antimicrob Agents Chemother 59:6288-95

Showing the most recent 10 out of 101 publications