This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: The overall mission of the Statistical Core is to provide support in the areas of study design, sample size estimation/statistical power analyses, statistical methodology and database management for the projects in the COBRE. The Statistical Core has a crucial role in not only providing statistical services but in contributing to the mentoring process for the junior principal investigators (JPIs) in developing their understanding of the importance of study design and data analysis. Objective: The activities of the Statistical Core are guided by the following 5 specific aims. (1) Consultation with Junior Principle Investigators (JPIs) on study design, sample size estimation, statistical analysis plan, and research proposal. (2) Development and management of database management system and quality control procedures. (3) Statistical analysis of study data, presentation and interpretation of results. (4) Educational services to support investigator development in study design and analysis. (5) Enhancement of statistical core services to bring state of the art capabilities to the COBRE. Methods: The Statistical Core actively recruited for an M.S. level biostatistician. Each project JPI met one on one with the Statistical Core PI to discuss study issues. Essential computing needs to support the research efforts of the COBRE were identified. We met with the EAC and received valuable feedback. Results: The Statistical Core successfully recruited an statistician. Dr.s Mercante and Simonsen presented seminars to the JPIs on design and analysis issues in statistics and epidemiology, respectively. A database has been developed for Dr. Leigh s project. We assisted Dr. Porter-Williams in designing a pilot study. We worked with Dr. Vastardis to resolve the issue of smoking. We purchased and installed a new server. Discussion: The Statistical Core has made significant progress towards the stated objectives and will continue to work closely with the JPIs to provide guidance and support for their research.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-5 (02))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State University Hsc New Orleans
Schools of Medicine
New Orleans
United States
Zip Code
Kher, Swapnil S; Struckhoff, Amanda P; Alberts, Arthur S et al. (2014) A novel role for p115RhoGEF in regulation of epithelial plasticity. PLoS One 9:e85409
Struckhoff, Amanda P; Rana, Manish K; Kher, Swapnil S et al. (2013) PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA. J Cell Sci 126:4514-26
Johnson, Clorinda C; Yu, Alika; Lee, Heeje et al. (2012) Development of a contemporary animal model of Candida albicans-associated denture stomatitis using a novel intraoral denture system. Infect Immun 80:1736-43
Rana, Manish K; Worthylake, Rebecca A (2012) Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility. J Biol Chem 287:21836-45
Xu, Xiaoming; Wang, Yapin; Liao, Sumei et al. (2012) Synthesis and characterization of antibacterial dental monomers and composites. J Biomed Mater Res B Appl Biomater 100:1151-62
Fan, Yuwei; Nelson, James R; Alvarez, Jason R et al. (2011) Amelogenin-assisted ex vivo remineralization of human enamel: Effects of supersaturation degree and fluoride concentration. Acta Biomater 7:2293-302
Kher, Swapnil S; Worthylake, Rebecca A (2011) Regulation of ROCKII membrane localization through its C-terminus. Exp Cell Res 317:2845-52
Fidel Jr, Paul L; Cutler, Jim E (2011) Prospects for development of a vaccine to prevent and control vaginal candidiasis. Curr Infect Dis Rep 13:102-7
Harriott, Melphine M; Noverr, Mairi C (2011) Importance of Candida-bacterial polymicrobial biofilms in disease. Trends Microbiol 19:557-63
Lee, H; Yu, A; Johnson, C C et al. (2011) Fabrication of a multi-applicable removable intraoral denture system for rodent research. J Oral Rehabil 38:686-90

Showing the most recent 10 out of 26 publications