The objective of the Center of Biomedical Research Excellence in the Molecular Basis of Human Disease (COBREMBHD) is to enhance the success of promising junior investigators at the University of Kentucky for competing for NIH grant support through the development of a research center focusing on understanding human disease at the molecular level. We will achieve this objective by: (1) assembling a group of established extramurally funded scientists who will serve as mentors for junior faculty serving as principal investigators on research projects. (2) providing these junior faculty with state-of-the-art training in concepts and techniques relevant to studying human disease with an emphasis on the application of structural biology to these projects, (3) establishing mentoring plans including milestones as the basis of the development program, (4) developing and supporting shared core facilities, (5) providing pilot grants for projects that will complement those of the junior faculty, (6) providing a seminar program stressing the latest advances in studying human diseases at the molecular level and techniques of structural biology and their application to biomedical research, (6) holding an annual retreat to evaluate and critique the progress of the junior faculty and (7) hiring promising new faculty to develop a critical mass of productive investigators in studying molecular aspects of human disease. Five tenure track Assistant Professors will serve as PIs on research projects that overlap in concepts and methodology. The junior investigators participating in the COBRE came from excellent postdoctoral experiences and are likely to benefit from the training program. Their projects apply one or more of the techniques of structural biology to studies related to human disease and have a high likelihood of developing into successful RO1 type research grants.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR020171-02
Application #
6945403
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Program Officer
Canto, Maria Teresa
Project Start
2004-09-01
Project End
2009-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
2
Fiscal Year
2005
Total Cost
$1,986,172
Indirect Cost
Name
University of Kentucky
Department
Biochemistry
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Stenslik, M J; Evans, A; Pomerleau, F et al. (2018) Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques. J Neurosci Methods 303:30-40
Kenlan, Dasha E; Rychahou, Piotr; Sviripa, Vitaliy M et al. (2017) Fluorinated N,N'-Diarylureas As Novel Therapeutic Agents Against Cancer Stem Cells. Mol Cancer Ther 16:831-837
Frasinyuk, Mykhaylo S; Zhang, Wen; Wyrebek, Przemyslaw et al. (2017) Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4). Org Biomol Chem 15:7623-7629
Shrestha, Sanjib K; Kril, Liliia M; Green, Keith D et al. (2017) Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents. Bioorg Med Chem 25:58-66
Cifuentes-Muñoz, Nicolás; Sun, Weina; Ray, Greeshma et al. (2017) Mutations in the Transmembrane Domain and Cytoplasmic Tail of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly. J Virol 91:
Burikhanov, Ravshan; Hebbar, Nikhil; Noothi, Sunil K et al. (2017) Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis. Cell Rep 18:508-519
Klimyte, Edita M; Smith, Stacy E; Oreste, Pasqua et al. (2016) Inhibition of Human Metapneumovirus Binding to Heparan Sulfate Blocks Infection in Human Lung Cells and Airway Tissues. J Virol 90:9237-50
Edgar, Rebecca J; Chen, Jing; Kant, Sashi et al. (2016) SpyB, a Small Heme-Binding Protein, Affects the Composition of the Cell Wall in Streptococcus pyogenes. Front Cell Infect Microbiol 6:126
Matveeva, Elena; Maiorano, John; Zhang, Qingyang et al. (2016) Involvement of PARP1 in the regulation of alternative splicing. Cell Discov 2:15046
Emanuelle, Shane; Brewer, M Kathryn; Meekins, David A et al. (2016) Unique carbohydrate binding platforms employed by the glucan phosphatases. Cell Mol Life Sci 73:2765-2778

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