This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This study is directed toward understanding adipocyte differentiation, a critical process that contributes to the development of excess adipose mass and obesity. While changes in the ECM and integrin receptor expression have been observed during adipocyte differentiation, the ability of these processes to regulate adipogenesis is largely unexplored. The overall GOAL of this proposed study is to elucidate the anti-adipogenic function of integrin 5. This goal will be accomplished by determining (1) whether the loss of integrin 5 expression promotes adipocyte differentiation and obesity; and (2) the mechanism whereby the 5 integrins regulates the Rac activity in preadipocytes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR020171-05
Application #
7720905
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2008-08-01
Project End
2009-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
5
Fiscal Year
2008
Total Cost
$73,737
Indirect Cost
Name
University of Kentucky
Department
Biochemistry
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
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